[老年人群中的人类近端着丝粒染色体关联]
[Human acrocentric chromosomal associations in old age].
作者信息
Lezhava T A
出版信息
Tsitol Genet. 1979 Nov-Dec;13(6):481-5.
PMID:552667
Abstract
Associations of satellite chromosome fibres of acrocentric chromosomes of the DD, GG and DG types were studied in persons aged from 80 to 114 years. It was found that the value of P (probability of joining of satellite fibres of two chromosomes in a group) is considerably less than the corresponding value for persons aged from 20 to 48 years. It is supposed that the decrease of the frequency of association at senile age is caused by heterochromatization of satellite fibres in the 13th and 14 chromosome pairs.
摘要
对年龄在80至114岁的人群中DD、GG和DG型近端着丝粒染色体的随体染色体纤维关联进行了研究。发现P值（一组中两条染色体随体纤维连接的概率）明显低于20至48岁人群的相应值。据推测，老年期关联频率的降低是由第13和14号染色体对中随体纤维的异染色质化引起的。
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