Lezhava T A
Tsitol Genet. 1984 Jan-Feb;18(1):40-6.
Ag-stained acrocentric chromosomes were cytogenetically studied in 20 individuals aged 20-50, 80 and in older ones. It is revealed that the number of Ag-positive nucleolus regions and association frequency of Ag-stained acrocentric chromosomes statistically decreased in the individuals of old age as compared with the middle-aged persons. This is supposed to be conditioned by heterochromatinization of the satellite stalks of the 13th, 21st and 22 d chromosomes in the process of ageing.
对20名年龄在20至50岁之间的个体、80名年龄较大的个体的近端着丝粒染色体进行了银染细胞遗传学研究。结果显示，与中年个体相比，老年个体中银阳性核仁区的数量以及银染近端着丝粒染色体的联合频率在统计学上有所下降。这被认为是由于在衰老过程中第13、21和22号染色体的随体柄异染色质化所致。
