Nash A S, Wright N G, Spencer A J, Thompson H, Fisher E W
Vet Rec. 1979 Jul 28;105(4):71-7. doi: 10.1136/vr.105.4.71.
A series of 13 cases of feline membranous nephropathy is presented. Two groups were distinguished clinically; eight cats had the nephrotic syndrome and five others were in renal failure but not nephrotic. The definitive diagnosis was based on histological, immunofluorescence and ultrastructural examinations of renal tissue obtained at renal biopsy or necropsy. Glomerular lesions were classified according to the degree of glomerular change into three distinct groups; mild, moderately severe and advanced. A relationship was established between the mild and moderately severe groups and cats with the nephrotic syndrome, and the advanced group and cats in renal failure. Diuretic therapy was satisfactory in initial control of oedema in the nephrotic cases. Monitoring of previously nephrotic cats for up to three years indicated that the disease is progressive, although in some cases it is sufficiently slow for a cat to live a relatively normal life without continuing treatment. The prognosis for cats presented in renal failure is hopeless.
本文报告了13例猫膜性肾病病例。临床上分为两组；8只猫患有肾病综合征，另外5只处于肾衰竭但未患肾病。最终诊断基于肾活检或尸检时获取的肾组织的组织学、免疫荧光和超微结构检查。根据肾小球变化程度将肾小球病变分为三个不同组；轻度、中度严重和重度。轻度和中度严重组与患有肾病综合征的猫之间，以及重度组与肾衰竭的猫之间建立了联系。利尿疗法对肾病病例水肿的初始控制效果良好。对先前患有肾病的猫进行长达三年的监测表明，该疾病呈进行性发展，尽管在某些情况下进展足够缓慢，猫无需持续治疗就能过上相对正常的生活。出现肾衰竭的猫预后无望。
