Syme Harriet M
Department of Veterinary Clinical Sciences, Royal Veterinary College, Hawkshead Lane, Hatfield, Hertfordshire AL97TA, UK.
J Feline Med Surg. 2009 Mar;11(3):211-8. doi: 10.1016/j.jfms.2009.01.003.
Numerous tests are available to the practitioner for quantifying proteinuria. It is important to understand the advantages and limitations of these tests and how the information gained can contribute to optimal patient management. Cats with chronic kidney disease or systemic hypertension, as well as geriatric cats without overt evidence of disease (including renal dysfunction), are at particular risk of proteinuria. Evidence base Several longitudinal studies of cats seen in first opinion clinics have shown an association between proteinuria and decreased survival time. However, it is unknown whether the deaths that occur in proteinuric cats are due to progression of renal disease because it is often difficult to ascribe a cause of death to a single underlying aetiology in clinical patients. It is also unknown whether proteinuria is contributing to disease progression in these cats or whether proteinuric renal disease is intrinsically more rapidly progressive. More aggressive investigation and management of patients with proteinuria may be appropriate since they are more likely to have progressive disease and/or increased mortality.
临床医生有多种检测方法可用于定量蛋白尿。了解这些检测方法的优缺点以及所获得的信息如何有助于优化患者管理非常重要。患有慢性肾病或系统性高血压的猫，以及没有明显疾病证据（包括肾功能不全）的老年猫，特别容易出现蛋白尿。循证依据 多项针对初诊诊所中猫的纵向研究表明，蛋白尿与生存时间缩短之间存在关联。然而，尚不清楚蛋白尿猫的死亡是否是由于肾病进展所致，因为在临床患者中，往往很难将死亡原因归结于单一潜在病因。也不清楚蛋白尿是否会促使这些猫的疾病进展，或者蛋白尿性肾病本身是否进展更快。对于蛋白尿患者，可能需要更积极的检查和管理，因为他们更有可能患有进展性疾病和/或死亡率增加。
