Hwang K K, Kelsey M I
Cancer Biochem Biophys. 1978;3(1):31-5.
Cholesterol-5 alpha, 6 alpha-epoxide has been implicated as an etiologic agent in human colon cancer. The epoxide is metabolized by human intestinal microflora to a product which was characterized by thin-layer and gas-liquid chromatography as well as combined gas-liquid chromatography-mass spectrometry. Chromatographic properties are identical with authentic cholestan-3 beta, 5 alpha, 6 beta-triol, and these results suggest that microbial epoxide hydrase activity is present in the human colon.
胆固醇-5α, 6α-环氧化物被认为是人类结肠癌的一种致病因素。该环氧化物被人类肠道微生物群代谢为一种产物，通过薄层色谱、气液色谱以及气液色谱-质谱联用对其进行了表征。其色谱特性与纯品胆甾烷-3β, 5α, 6β-三醇相同，这些结果表明人类结肠中存在微生物环氧化物水解酶活性。
