Brayda-Bruno M, Levi A C
Boll Soc Ital Biol Sper. 1979 Sep 30;55(18):1902-8.
The Authors study through ultrastructural observations the sequence of processes concerning the appearance and the depositing of the neuromelanic pigment in the neurons of dog mesencephalic substantia nigra nucleus at different ages. The results are as follows: in the one year old dog, in a low percentage of lysosome-like oval organelles, few masses, strongly electron-dense, appear on the matrix. In the five year old dog, these masses are deposited and increased in quantity inside many more organelles. In the specimens extracted from older dogs, these organelles, characterized moreover by the presence of lipidic globules, merging in groups, became larger and more irregular. The Authors discuss the results obtained with the ultrastructural observation, compared with those obtained with the optical methods.
作者通过超微结构观察，研究了不同年龄犬中脑黑质核神经元中神经黑色素的出现和沉积过程的顺序。结果如下：在1岁的犬中，在低比例的溶酶体样椭圆形细胞器中，基质上出现少量电子密度很高的团块。在5岁的犬中，这些团块在更多的细胞器内沉积且数量增加。在从老年犬提取的标本中，这些细胞器除了含有脂滴外，还成群融合，变得更大且更不规则。作者将超微结构观察得到的结果与光学方法得到的结果进行了比较，并对这些结果进行了讨论。
