Levi A C, De Mattei M, Graziano E
Boll Soc Ital Biol Sper. 1982 Feb;58(3-4):165-8.
The AA. study the behaviour of neuromelanic pigment in the substantia nigra of cats' mesencephalon. To this aim they suppress a first group of animals with MgSO4; a second group with a substance whose action is narcotic and curare-like. They carry out the observations on mesencephalon microtomic sections, some stained with hematoxylin, some treated with PAS reaction and some with Sudan Black. The results are: 1)- in the perikaryon of substantia nigra pars compacta neurons of cats suppressed with MgSO4, the pigment, absent in the early age of life, appears in adult age. It is characterized by brownish-yellow granulations, either scattered or clustered together. This finding is substantially similar to that observed in dogs' substantia nigra. 2)- The substantia nigra neurons of the mesencephalon taken from cats suppressed with a curare-like substance, appear instead, almost wholly, without the peculiar neuromelanic granulations. However intracytoplasmic bodies stained with hematoxylin and PAS positive, can be observed. In order to establish the morphological and histochemical events which occur in the substantia nigra neurons in depigmentation induced in this way the AA. consider further investigations absolutely necessary.
作者们研究了猫中脑黑质中神经黑色素的行为。为此，他们用硫酸镁抑制第一组动物；用一种具有麻醉和箭毒样作用的物质抑制第二组动物。他们在中脑切片上进行观察，一些切片用苏木精染色，一些用PAS反应处理，一些用苏丹黑处理。结果如下：1）在被硫酸镁抑制的猫的致密部黑质神经元的胞体中，这种在生命早期不存在的色素在成年期出现。其特征是棕黄色颗粒，或分散或聚集在一起。这一发现与在狗的黑质中观察到的基本相似。2）相反，取自被箭毒样物质抑制的猫的中脑黑质神经元几乎完全没有特殊的神经黑色素颗粒。然而，可以观察到用苏木精染色且PAS阳性的胞浆内小体。为了确定以这种方式诱导的黑质神经元色素脱失中发生的形态学和组织化学变化，作者们认为进一步的研究绝对必要。
