Bairati A, Perotti M E, Vitellaro Zuccarello L, Della Morte E
Bull Assoc Anat (Nancy). 1979 Sep;63(182):255-62.
Ten testicular biopsies from adult males with agenesis of the vas deferens have been investigated with light and electron microscopy. The ultrastructural study of SERTOLI cells has demonstrated that: (a) the junctions between SERTOLI cells and between SERTOLI and germinal cells retain their normal ultrastructural features. (b) Lanthanum permeates SERTOLI cells tight junctions, but its diffusion towards the adluminal compartment is prevented. (c) SERTOLI cells present unusual amounts of cytoplasmic inclusions, especially lipofuscin granules. A relationship between these inclusions and phagocytosis has not been demonstrated. (d) "Dark" SERTOLI cells which show alterations of their typical junctional complex have been frequently observed, although their frequency varies among the different patients. The results are discussed in relation to diagnostic significance of the ultrastructural study of testicular biopsies.
对10例患有输精管缺如的成年男性的睾丸活检组织进行了光镜和电镜研究。对支持细胞的超微结构研究表明：（a）支持细胞之间以及支持细胞与生殖细胞之间的连接保留了其正常的超微结构特征。（b）镧可透过支持细胞的紧密连接，但向管腔内分泌物的扩散受到阻止。（c）支持细胞存在异常数量的胞质内含物，尤其是脂褐素颗粒。尚未证实这些内含物与吞噬作用之间的关系。（d）尽管不同患者之间其出现频率有所不同，但经常观察到“暗”支持细胞，其典型连接复合体出现改变。结合睾丸活检超微结构研究的诊断意义对结果进行了讨论。
