福斯曼抗血清对过敏反应性组胺释放的抑制作用。I. 反应及抑制剂的特性
Inhibition of anaphylactic histamine release by Forssman antiserum. I. Characteristics of the reaction and inhibitor.
作者信息
Duravetz J, Baumal R, Broder I
出版信息
Immunology. 1976 Jan;30(1):89-99.
Forssman antiserum produced in rabbits immunized with sheep erythrocyte stromata was found to contain an IgG antibody which inhibited both passive anaphylactic sensitization of guinea-pig lung and also histamine-releasing activity of soluble immune complexes. This Forssman antibody did not itself cause histamine release or depletion of lung histamine stores. The IgM haemolysin component of the Forssman antiserum was not associated with inhibitory activity. The inhibition by the IgG Forssman antibody differed from that of normal rabbit gammaglobulin both in its irreversible character and in being absorbed by sheep erythrocytes. The inhibitory antibody had no effect on the histamine-releasing activity of compound 48/80, anaphylatoxin or reversed anaphylaxis. It was concluded that IgG Forssman antibody probably blocks the tissue receptor(s) for anaphylactic antibody in guinea-pig lung.
在用绵羊红细胞基质免疫的兔子中产生的福斯曼抗血清被发现含有一种IgG抗体，该抗体既能抑制豚鼠肺的被动过敏致敏，又能抑制可溶性免疫复合物的组胺释放活性。这种福斯曼抗体本身不会引起组胺释放或肺组胺储存的耗竭。福斯曼抗血清的IgM溶血素成分与抑制活性无关。IgG福斯曼抗体的抑制作用在其不可逆特性以及被绵羊红细胞吸收方面均与正常兔丙种球蛋白不同。该抑制性抗体对化合物48/80、过敏毒素或反向过敏反应的组胺释放活性没有影响。得出的结论是，IgG福斯曼抗体可能会阻断豚鼠肺中过敏抗体的组织受体。
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