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1
ON THE SENSITIZING PROPERTIES OF SOME NORMAL AND PATHOLOGIC HUMAN IMMUNE GLOBULINS AND FRAGMENTS OBTAINED BY PAPAIN OF PEPSIN DIGESTION.关于某些正常和病理性人免疫球蛋白以及木瓜蛋白酶或胃蛋白酶消化产生的片段的致敏特性
Immunology. 1963 Sep;6(5):434-8.
2
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J Exp Med. 1963 Jan 1;117(1):81-104. doi: 10.1084/jem.117.1.81.
3
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4
PROTEIN-PROTEIN INTERACTIONS AMONG L POLYPEPTIDE CHAINS OF BENCE-JONES PROTEINS AND HUMAN GAMMA-GLOBULINS.本-周蛋白L多肽链与人类γ球蛋白之间的蛋白质-蛋白质相互作用
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J Exp Med. 1962 Mar 1;115(3):641-53. doi: 10.1084/jem.115.3.641.
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引用本文的文献

1
THE CATABOLISM OF HOMOLOGOUS AND HETEROLOGOUS 7S GAMMA GLOBULIN FRAGMENTS.同源和异源7Sγ球蛋白片段的分解代谢
J Exp Med. 1965 Mar 1;121(3):323-38. doi: 10.1084/jem.121.3.323.
2
Human reagins: appraisal of the properties of the antibody of immediate-type hypersensitivity.人反应素：速发型超敏反应抗体特性的评估
Bacteriol Rev. 1972 Sep;36(3):311-60. doi: 10.1128/br.36.3.311-360.1972.
3
Affinity of immunoglobulin for heterologous tissue mast cells. A study with the fluorescent antibody method.免疫球蛋白对异种组织肥大细胞的亲和力。荧光抗体法研究。
Immunology. 1968 Jul;15(1):51-64.
4
Isolation of rabbit IgA antihapten antibody and demonstration of skin-sensitizing activity in homologous skin.兔IgA抗半抗原抗体的分离及在同源皮肤中皮肤致敏活性的证明。
J Exp Med. 1966 Jan 1;123(1):173-90. doi: 10.1084/jem.123.1.173.
5
Inhibition of anaphylactic histamine release by Forssman antiserum. I. Characteristics of the reaction and inhibitor.福斯曼抗血清对过敏反应性组胺释放的抑制作用。I. 反应及抑制剂的特性
Immunology. 1976 Jan;30(1):89-99.

本文引用的文献

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Neutralizing antibody to polioviruses in normal human urine.正常人尿液中针对脊髓灰质炎病毒的中和抗体。
J Clin Invest. 1962 Apr;41(4):805-15. doi: 10.1172/JCI104538.
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The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.用结晶木瓜蛋白酶对兔γ球蛋白和抗体进行水解。
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Studies on conditions associated with disturbed gamma globulin formation (gammopathies).与γ球蛋白生成紊乱相关病症（γ球蛋白病）的研究。
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4
Passive cutaneous anaphylaxis with antibody fragments.抗体片段介导的被动皮肤过敏反应
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Complement fixation by antibody fragments.抗体片段介导的补体固定
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6
The relative transmission of the fractions of papain hydrolyzed homologous gamma-globulin from the uterine cavity to the foetal circulation in the rabbit.木瓜蛋白酶水解的同源γ球蛋白各组分从兔子宫腔到胎儿循环的相对传递情况。
Proc R Soc Lond B Biol Sci. 1960 Mar 1;151:478-82. doi: 10.1098/rspb.1960.0011.
7
Physicochemical and immunologic studies of gamma globulins of normal human urine.正常人尿液γ球蛋白的物理化学与免疫学研究
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8
The solubilization of microsomal antibody activity by the specific interaction between the crystallizable fraction of gamma-globulin and lymphnode microsomes.γ球蛋白可结晶部分与淋巴结微粒体之间的特异性相互作用使微粒体抗体活性溶解。
Proc Natl Acad Sci U S A. 1961 Jun 15;47(6):767-78. doi: 10.1073/pnas.47.6.767.
9
Studies on the immunologic mechanism of anaphylaxis. II. Sensitizing and combining capacity in vivo of fractions separated from papain digests of antihapten antibody.过敏反应的免疫机制研究。II. 抗半抗原抗体木瓜蛋白酶消化产物各组分的体内致敏及结合能力
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10
Anuphylactic reactions in the skin of the guinea pig with high and low molecular weight antibodies and gamma globulins.豚鼠皮肤中高分子量和低分子量抗体及γ球蛋白的过敏反应。
J Exp Med. 1960 Nov 1;112(5):953-61. doi: 10.1084/jem.112.5.953.

关于某些正常和病理性人免疫球蛋白以及木瓜蛋白酶或胃蛋白酶消化产生的片段的致敏特性

ON THE SENSITIZING PROPERTIES OF SOME NORMAL AND PATHOLOGIC HUMAN IMMUNE GLOBULINS AND FRAGMENTS OBTAINED BY PAPAIN OF PEPSIN DIGESTION.

作者信息

FRANKLIN E C, OVARY Z

出版信息

Immunology. 1963 Sep;6(5):434-8.

PMID:14069719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1423275/
Abstract

Although normal γA (βA) globulins, myeloma proteins, as well as Bence-Jones proteins and normal human urine γ globulins cross-react with 7S γ globulins, none of these proteins can sensitize the skin of the guinea-pig to give a reverse passive cutaneous anaphylaxis reaction. The 3.5S fragments of human antisera to horse serum proteins can no longer give passive cutaneous anaphylaxis reactions, but fragment C and probably A can inhibit the passive cutaneous anaphylaxis reaction of the original antiserum. By reverse passive cutaneous anaphylaxis, negative results were obtained with each of the three fragments or the 5S pepsin digest.

摘要

尽管正常的γA（βA）球蛋白、骨髓瘤蛋白、本斯·琼斯蛋白以及正常人尿γ球蛋白与7Sγ球蛋白发生交叉反应，但这些蛋白均不能使豚鼠皮肤致敏而产生反向被动皮肤过敏反应。人抗马血清蛋白抗血清的3.5S片段不再产生被动皮肤过敏反应，但C片段以及可能的A片段可抑制原始抗血清的被动皮肤过敏反应。通过反向被动皮肤过敏反应，三种片段中的每一种或5S胃蛋白酶消化产物均得到阴性结果。