Boriani S, Laus M
Ital J Orthop Traumatol. 1978 Dec;4(3):353-7.
265 cases of solitary chondroma, multiple chondromas and chondromatosis were analysed. Two hundred cases had a long term follow up of 1-50 years (average ten years). Recurrence after surgical removal is rare. It is exceptional for malignancy to develop in chondromas of the hand. Malignant degeneration (chondrosarcoma, fibrosarcoma, etc.) was found in 12 per cent of the solitary chondromas and in 32 per cent of the multiple chondromas and chondromatosis involving the bones elsewhere than in the hand. The first of these figures is probably excessive, since many of the solitary chondromas elsewhere than in the hand remain asymptomatic and unrecognised; but the second figure is probably too low, since the risk of sarcomatous degeneration remains present throughout the patient's life.
对265例孤立性软骨瘤、多发性软骨瘤和软骨瘤病进行了分析。200例进行了1至50年的长期随访（平均10年）。手术切除后复发罕见。手部软骨瘤发生恶变实属例外。在手部以外骨骼的孤立性软骨瘤中，12%发生了恶性变（软骨肉瘤、纤维肉瘤等）；在手部以外骨骼的多发性软骨瘤和软骨瘤病中，32%发生了恶性变。前一个数字可能偏高，因为手部以外的许多孤立性软骨瘤仍无症状且未被发现；但后一个数字可能偏低，因为肉瘤样变的风险在患者一生中始终存在。
