McLoughlin Gregory S, Sciubba Daniel M, Wolinsky Jean-Paul
Division of Neurosurgery, University of Saskatchewan, University Hospital, 103 Hospital Drive, Saskatoon, Saskatchewan, S7N 0W8, Canada.
Neurosurg Clin N Am. 2008 Jan;19(1):57-63. doi: 10.1016/j.nec.2007.09.007.
Chondromas and chondrosarcomas are cartilage-forming tumors that occur rarely in the spine. These neoplasms exist on opposite ends of the pathologic spectrum, ranging from the benign chondroma to the malignant, high-grade chondrosarcoma. Unlike other sarcomas, a patient's long-term prognosis is influenced by the grade of the tumor. A complete en bloc resection is the ideal method of surgical management. This method holds especially true for chondrosarcomas, and can result in prolonged survival. These tumors are resistant to conventional chemotherapy and radiation therapy. Hypofractionated stereotactic radiation therapy may slow tumor progression, although the long-term effect of this modality is unknown.
软骨瘤和软骨肉瘤是罕见发生于脊柱的软骨形成性肿瘤。这些肿瘤处于病理谱的两端,从良性软骨瘤到恶性、高级别软骨肉瘤。与其他肉瘤不同,患者的长期预后受肿瘤分级影响。整块完整切除是理想的手术治疗方法。这种方法对软骨肉瘤尤其适用,可延长生存期。这些肿瘤对传统化疗和放疗耐药。短程立体定向放射治疗可能会减缓肿瘤进展,尽管这种治疗方式的长期效果尚不清楚。