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离子通过生物膜运动的动力学理论模型。II. 离子间选择性

Kinetic theory model for ion movement through biological membranes. II. Interionic selectivity.

作者信息

Mackey M C

出版信息

Biophys J. 1971 Jan;11(1):91-7. doi: 10.1016/S0006-3495(71)86197-0.

DOI:10.1016/S0006-3495(71)86197-0
PMID:5539002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1484033/
Abstract

The equation presented in the previous paper for steady-state membrane ionic current as a function of externally applied electric field strength is numerically analyzed to determine the influence of ionic and membrane molecule parameters on current densities. The model displays selectivity between different ions. A selectivity coefficient S(i), defined as the ratio of current carried by an ionic species i at a given field strength to the current carried by a reference species at the same field strength, has the following properties: (a) S(i) is a function of electric field strength except for ion-membrane molecule interactions yielding velocity independent collision frequencies; (b) for ion-membrane molecule interactions characterized by a collision frequency that is a decreasing (increasing) function of increasing ionic velocity, ions whose S(i) > 1 (<1) at zero field strength will show maxima (minima) (minima[maxima]) in their S(i) vs. electric field strength curves.

摘要

对上一篇论文中给出的稳态膜离子电流作为外部施加电场强度函数的方程进行数值分析，以确定离子和膜分子参数对电流密度的影响。该模型显示了不同离子之间的选择性。选择性系数S(i)定义为在给定场强下离子物种i所携带的电流与在相同场强下参考物种所携带的电流之比，具有以下性质：(a) 除了离子 - 膜分子相互作用产生与速度无关的碰撞频率外，S(i)是电场强度的函数；(b) 对于以碰撞频率为离子速度增加的递减（递增）函数为特征的离子 - 膜分子相互作用，在零场强下S(i)>1(<1)的离子将在其S(i)与电场强度曲线中显示最大值（最小值）（最小值[最大值]）。

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引用本文的文献

1
Kinetic theory model for ion movement through biological membranes. I. Field-dependent conductances in the presence of solution symmetry.离子通过生物膜运动的动力学理论模型。I. 溶液对称情况下的场依赖电导率
Biophys J. 1971 Jan;11(1):75-90. doi: 10.1016/S0006-3495(71)86196-9.
2
A systems theoretical approach to biological membranes. I. Formulation of a generalized model for electrical phenomena in excitable membranes.一种关于生物膜的系统理论方法。I. 可兴奋膜电现象广义模型的构建。
Kybernetik. 1973 Mar;12(3):119-32. doi: 10.1007/BF00289164.
3
Microscopic model for selective permeation in ion channels.离子通道选择性渗透的微观模型。
Biophys J. 1991 Jul;60(1):238-51. doi: 10.1016/S0006-3495(91)82046-X.

本文引用的文献

1
Voltage clamp studies on the effect of internal cesium ion on sodium and potassium currents in the squid giant axon.关于内部铯离子对枪乌贼巨大轴突中钠电流和钾电流影响的电压钳研究。
J Gen Physiol. 1966 Nov;50(2):279-93. doi: 10.1085/jgp.50.2.279.
2
Voltage clamp experiments on internally perfused giant axons.对内部灌注的巨大轴突进行电压钳实验。
J Physiol. 1965 Oct;180(4):788-820. doi: 10.1113/jphysiol.1965.sp007732.
3
Ammonium ion currents in the squid giant axon.枪乌贼巨大轴突中的铵离子电流。
J Gen Physiol. 1969 Mar;53(3):342-61. doi: 10.1085/jgp.53.3.342.
4
Kinetic theory model for ion movement through biological membranes. I. Field-dependent conductances in the presence of solution symmetry.离子通过生物膜运动的动力学理论模型。I. 溶液对称情况下的场依赖电导率
Biophys J. 1971 Jan;11(1):75-90. doi: 10.1016/S0006-3495(71)86196-9.