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Inhibition of 3H-thymidine incorporation into human lymphocytes by dialyzable material of streptokinase- streptodornase.

作者信息

Kuroume T, Suzuki S, Nemoto H, Shibasaki M, Matsumura T

出版信息

Int Arch Allergy Appl Immunol. 1976;50(4):402-15. doi: 10.1159/000231530.

DOI:10.1159/000231530
PMID:55392
Abstract

Using the 3H-thymidine incorporation test, the lymphocyte-stimulating activity of streptokinase-streptodornase (SK-SD, Varidase) and its fractions were evaluated. The dose-response curves of all the preparations except the third fraction had two peaks with the maximum around 5 and 40 mug. The dialyzable fraction of Sk-SD (D-SK-SD) occupying approximately half of the original sample had almost no lymphocyte-stimulating activity; and conversely, it had a potent inhibitory effect on the 3H-thymidine incorporation into lymphocytes that normally occurs with non-dialyzable SK-SD (ND-SK-SD), PPD and PHA-P. Therefore, it will be desirable to remove the dialyzable fraction from the commercial SK-SD preparation when it is used for the determination of the capacity of cellular immunity against tsk-sd.

摘要

相似文献

1
Inhibition of 3H-thymidine incorporation into human lymphocytes by dialyzable material of streptokinase- streptodornase.
Int Arch Allergy Appl Immunol. 1976;50(4):402-15. doi: 10.1159/000231530.
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[Studies of streptokinase-streptodornase (SK-SD) preparation on immunological responses. The effect of the immunosuppressive factor contained in SK-SD preparation].[链激酶-链道酶（SK-SD）制剂对免疫反应的研究。SK-SD制剂中所含免疫抑制因子的作用]
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