Han T
Clin Exp Immunol. 1973 Jan;13(1):165-70.
blastogenic response of sensitized human lymphocytes to specific antigens was significantly enhanced by neuraminidase treatment. No such enhancement was noted when the unsensitized lymphocytes were treated with this enzyme. An enhancement effect of neuraminidase on the lymphocyte response to concanavalin A or pokeweed mitogen (weak mitogens) was also noted; the enzyme had no effect on phytohaemagglutinin (strong mitogen)-induced blasto-genesis. The increased reactivity of lymphocytes is probably related to changed physical and functional properties of the cells after treatment with neuraminidase.
神经氨酸酶处理显著增强了致敏的人淋巴细胞对特定抗原的增殖反应。当用这种酶处理未致敏的淋巴细胞时，未观察到这种增强作用。还注意到神经氨酸酶对淋巴细胞对刀豆球蛋白A或商陆有丝分裂原（弱有丝分裂原）的反应有增强作用；该酶对植物血凝素（强有丝分裂原）诱导的细胞增殖没有影响。淋巴细胞反应性的增加可能与用神经氨酸酶处理后细胞的物理和功能特性改变有关。
