Snell E, Stackiw W, Wilt J C
Can Med Assoc J. 1971 Feb 6;104(3):206-9.
Five hundred and seventy female health science personnel between the ages of 18 and 25 years were examined for antibodies to the rubella virus by the hemagglutination inhibition technique. Approximately 90% of the subjects had a titre of 1:20 or higher. The geometric mean titre of the positive sera was 1:251. Sixty-four of the 77 persons with an antibody of 1:20 or less volunteered to take the vaccine and were examined six weeks later for the development of antibodies. The conversion rate for the 51 persons who were negative at the dilution of 1:20 at the outset was 94%; the rate of antibody increment for the 13 persons who were positive at 1:20 at the outset was 77%. Among the 51 persons who developed antibodies, the geometric mean titre was 1:57 and among the other 13 it was 1:49. Although the trial was conducted in adult females, the number of side effects from the vaccine was remarkably scanty and insignificant. This trial would seem to emphasize the importance of avoiding the use of rubella vaccine in women of child-bearing age without first excluding pregnancy with meticulous care and using active and controllable contraceptive methods for the two months following vaccination.
采用血凝抑制技术对570名年龄在18至25岁之间的女性健康科学人员进行了风疹病毒抗体检测。约90%的受试者滴度为1:20或更高。阳性血清的几何平均滴度为1:251。77名抗体滴度为1:20或更低的人员中有64人自愿接种疫苗，并在六周后检测抗体的产生情况。最初在1:20稀释度时呈阴性的51人的转化率为94%；最初在1:20时呈阳性的13人的抗体增加率为77%。在产生抗体的51人中，几何平均滴度为1:57，在另外13人中为1:49。尽管该试验是在成年女性中进行的，但疫苗的副作用数量极少且不显著。该试验似乎强调了在育龄妇女中避免使用风疹疫苗的重要性，除非首先经过仔细检查排除怀孕，并在接种疫苗后的两个月内采用积极且可控的避孕方法。
