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泛影葡胺及泛影葡胺钠的肾脏清除率研究(作者译)

[Investigation on the renal clearance of metylglucamine diatrizoate and of sodium and metylglucamine diatrizoate (author's transl)].

作者信息

Michelassi P L, Rindi P, Pilone N, Simonetti F

出版信息

Radiol Med. 1979 Sep;65(9):611-4.

PMID:554248
Abstract

In 14 patients the kinetics has been studied of two contrast media labelled with 131I, and namely of MGM diatrizoate and of diatrizoate of sodium and MGM. The clearance was determined both at basal concentrations and in double concentration by means of external counting. The results were statistically studied by means of the linear regression method. The authors conclude that the MGM diatrizoate is exclusively eliminated through the glomeruli both in basal and double concentration. The diatrizoate of sodium and MGM is eliminated in low concentration through the glomeruli, while in double concentration it is partially eliminated through the tubuli.

摘要

对14名患者进行了研究,观察了两种用131I标记的造影剂的动力学情况,即甲葡胺泛影酸盐以及泛影酸钠和甲葡胺泛影酸盐。通过体外计数法测定了基础浓度和双倍浓度时的清除率。采用线性回归法对结果进行了统计学研究。作者得出结论,无论是基础浓度还是双倍浓度时,甲葡胺泛影酸盐均仅通过肾小球滤过清除。泛影酸钠和甲葡胺泛影酸盐在低浓度时通过肾小球滤过清除,而在双倍浓度时则部分通过肾小管清除。

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