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大鼠在适应温暖和寒冷过程中下丘脑去甲肾上腺素和5-羟色胺水平的变化。

Changes in hypothalamic noradrenaline and 5-hydroxytryptamine levels during the development of warm- and cold-adaptation in the rat.

作者信息

Hahn Z, Szelényi Z

出版信息

Acta Physiol Acad Sci Hung. 1979;54(3):245-9.

PMID:554440
Abstract

Hypothalamic 5-hydroxytryptamine (5-HT) and noradrenaline (NA) as well as plasma corticosterone levels were studied in male rats after 1, 2, 4 and 6 weeks of exposure to 4--7 or 30--31 degrees C. An increase of the NA concentration and a decrease of the 5-HT level was observed after the first week in both cold and warm environment together with an increase of plasma corticosterone levels in both groups. NA, 5-HT and plasma corticosterone levels returned to normal in cold-exposed animals by the 6th week whereas in warm-acclimated rats NA and corticosterone levels regained their initial values and 5-HT concentrations remained low. Changes by the end of the first week of exposure may result from the thermal stress. The low 5-HT levels of warm-adapted animals at the end of the 6th week were probably secondary to the process of adaptation.

摘要

研究了雄性大鼠在暴露于4-7或30-31摄氏度环境1、2、4和6周后下丘脑5-羟色胺(5-HT)、去甲肾上腺素(NA)以及血浆皮质酮水平。在寒冷和温暖环境中,第一周后均观察到NA浓度升高、5-HT水平降低,同时两组血浆皮质酮水平均升高。暴露于寒冷环境的动物在第6周时,NA、5-HT和血浆皮质酮水平恢复正常;而在适应温暖环境的大鼠中,NA和皮质酮水平恢复到初始值,5-HT浓度仍较低。暴露第一周结束时的变化可能是热应激所致。适应温暖环境的动物在第6周结束时5-HT水平较低可能是适应过程的继发结果。

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