Stimmesse B, Daoudal P, Boillot A, Bald P, Rozenbaum A, Barale F
Anesth Analg (Paris). 1979;36(11-12):565-6.
The authors report a case of fatal pancytopenia associated with sulfamethoxazole-trimethoprim therapy in a patient with folic acid deficiency. The mechanism is a matter of speculation, but the most attractive view is that the inhibiting effect of trimethoprim on dehydrofolate reductase can involve pancytopenia in patients with folic acid deficiency.
