乙酰胆碱-毒扁豆碱在肾上腺素诱发心室自律性方面的协同作用。

The synergism acetylcholine-eserine in the epinephrine induced ventricular automaticity.

作者信息

Orsetti M, Fundarò A, Molinengo L

出版信息

Boll Soc Ital Biol Sper. 1979 Apr 30;55(8):795-8.

Abstract

Heart ventricular strips of the rat in Krebs solution were used to test the synergism acetylcholine-eserine. Ventricular automaticity induced by epinephrine 1 10(-6) is inhibited by acetylcholine (a 50% reduction of the automatism is observed with acetylcholine 1,23 10(-8) while four different concentrations of eserine cause an evident potentiation of the effect of acetylcholine (with eserine a 10(-5) the ED50 of acetylcholine is 2,57 10(-14)). It is concluded that the synergism eserine-acetylcholine is a synergism with potentiation and the acetylcholine introduced in the Krebs solution interacts with receptors different from those activated by the acetylcholine which accumulates when cholinesterase is inhibited by eserine.

摘要

用置于克雷布斯溶液中的大鼠心室肌条来测试乙酰胆碱 - 毒扁豆碱的协同作用。肾上腺素1×10⁻⁶ 所诱导的心室自律性会被乙酰胆碱抑制（当乙酰胆碱浓度为1.23×10⁻⁸ 时，可观察到自律性降低50%），而四种不同浓度的毒扁豆碱会明显增强乙酰胆碱的作用（当毒扁豆碱浓度为1×10⁻⁵ 时，乙酰胆碱的半数有效剂量为2.57×10⁻¹⁴）。得出的结论是，毒扁豆碱 - 乙酰胆碱的协同作用是一种具有增强作用的协同作用，并且在克雷布斯溶液中加入的乙酰胆碱与毒扁豆碱抑制胆碱酯酶时积累的乙酰胆碱所激活的受体不同。