Elaeva N L, Stroikov Iu N
Vopr Med Khim. 1978 Jul-Aug;24(4):461-4.
Incorporation of labelled precursors into total and nuclear DNA of liver tissue was inhibited after administration into animals of eserine at a dose 0.1--0.2 mg/100 g of body weight. Simultaneously, DNAase activity was increased and cholinesterase activity was inhibited in liver tissue. The DNA synthesis was inhibited in liver slices, if they were incubated with 2.10(-6) M eserine. The DNAase activity was unaltered in vitro. A cholinolytic compound metacin, pre-administered into the animals, was ineffective at dose of 1 mg/kg; it slightly decreased the effect of eserine at dose of 0.25 mg/kg.
给动物注射剂量为0.1 - 0.2毫克/100克体重的毒扁豆碱后，肝脏组织中标记前体掺入总DNA和核DNA的过程受到抑制。同时，肝脏组织中的DNA酶活性增加，胆碱酯酶活性受到抑制。如果将肝切片与2×10⁻⁶M毒扁豆碱一起孵育，DNA合成会受到抑制。DNA酶活性在体外未发生改变。预先给动物注射抗胆碱化合物麦他西平，剂量为1毫克/千克时无效；剂量为0.25毫克/千克时，它会略微降低毒扁豆碱 的作用。
