氧化震颤素对豚鼠离体回肠标本作用机制的研究。
Investigation of the mechanism of action of oxotremorine on the guinea-pig isolated ileum preparation.
作者信息
Cox B, Hecker S E
出版信息
Br J Pharmacol. 1971 Jan;41(1):19-25. doi: 10.1111/j.1476-5381.1971.tb09931.x.
Abstract
- The effects of oxotremorine on the guinea-pig ileum have been investigated to determine whether any component of its action is due to acetylcholine release.2. Log dose-response curves to oxotremorine and acetylcholine were similar and both drugs were competitively antagonized by atropine.3. Mipafox potentiated acetylcholine but not oxotremorine.4. No evidence of an indirect component of the action of oxotremorine was obtained using various pharmacological procedures (tetrodotoxin, morphine, cooling, procaine and hemicholinium-3).5. Oxotremorine had no effect on acetylcholine release from mipafox treated ileum but decreased the release from physostigmine treated ileum.6. It is concluded that oxotremorine acts directly on muscarinic receptors and not by releasing acetylcholine.
摘要
已对氧化震颤素对豚鼠回肠的作用进行了研究，以确定其作用的任何成分是否归因于乙酰胆碱的释放。
氧化震颤素和乙酰胆碱的对数剂量-反应曲线相似，两种药物均被阿托品竞争性拮抗。
丙胺氟磷增强了乙酰胆碱的作用，但未增强氧化震颤素的作用。
使用各种药理学方法（河豚毒素、吗啡、冷却、普鲁卡因和半胱氨酸-3）未获得氧化震颤素作用存在间接成分的证据。
氧化震颤素对丙胺氟磷处理的回肠中乙酰胆碱的释放没有影响，但减少了毒扁豆碱处理的回肠中乙酰胆碱的释放。
得出的结论是，氧化震颤素直接作用于毒蕈碱受体，而不是通过释放乙酰胆碱起作用。
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引用本文的文献
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