锰对豚鼠离体回肠制剂致痉挛作用的研究。
Investigation of the spasmogenic effect of manganese on the guineapig isolated ileum preparation.
作者信息
Schnieden H, Weston A H
出版信息
Br J Pharmacol. 1969 Jul;36(3):496-509. doi: 10.1111/j.1476-5381.1969.tb08006.x.
Abstract
- The mechanism of the manganese-induced spasm of the guinea-pig ileum was investigated using agents known to modify nerve function. The spasm was reduced by cooling, tetrodotoxin, procaine, Botulinus toxin (Type A), hyoscine and pempidine. It was potentiated by mipafox.2. In the presence of manganese, the release of acetylcholine from the ileum was greatly increased.3. Tetrodotoxin prevented the manganese-induced increase in acetylcholine output from the ileum but had no significant effect on the spontaneous acetylcholine output.4. It is suggested that the manganese-induced spasm of the ileum results from an action on intramural cholinergic nerves.
摘要
利用已知可改变神经功能的药物，对锰诱导的豚鼠回肠痉挛机制进行了研究。冷却、河豚毒素、普鲁卡因、肉毒杆菌毒素（A型）、东莨菪碱和潘必定可减轻痉挛。米帕明可增强痉挛。
在有锰存在的情况下，回肠中乙酰胆碱的释放大幅增加。
河豚毒素可阻止锰诱导的回肠乙酰胆碱释放增加，但对自发的乙酰胆碱释放无显著影响。
提示锰诱导的回肠痉挛是由对肠壁内胆碱能神经的作用所致。
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