Hutchison D C, Cook P J, Barter C E, Harris H, Hugh-Jones P
Br Med J. 1971 Mar 27;1(5751):689-94. doi: 10.1136/bmj.1.5751.689.
Of 72 patients with radiological evidence of pulmonary emphysema, emphysema occurred either alone or in association with bronchitis in 61, and 8 of these (13%) were found to have alpha(1)-antitrypsin deficiency. The main features of this condition are: exertional dyspnoea of relatively early onset (generally between 30 and 45 years of age), severely impaired FEV(1) and T(L)CO, and radiological emphysema predominantly affecting the lower zones of the lungs. It is probable that any patient with all the above abnormalities has alpha(1)-antitrypsin deficiency. There is evidence to suggest that cigarette smoking may hasten the onset of this type of emphysema.
在72例有肺气肿影像学证据的患者中，61例单独发生肺气肿或合并支气管炎，其中8例（13%）被发现有α1-抗胰蛋白酶缺乏。这种疾病的主要特征是：相对较早发病（一般在30至45岁之间）的劳力性呼吸困难、FEV(1)和T(L)CO严重受损，以及主要影响肺下部区域的放射性肺气肿。任何有上述所有异常的患者都有可能患有α1-抗胰蛋白酶缺乏。有证据表明吸烟可能会加速这种类型肺气肿的发病。
