Lamanna A, Periti P
Quad Sclavo Diagn. 1979 Jun;15 Suppl 1:377-85.
After some general considerations on the validity of antibiograms as a therapeutic guide, three methods are described and analyzed. Bacterial chemosensitivity to antimicrobic drugs were tested by the following methods: diffusion, dilution and automized methods. Only when transferred into routine laboratory methods that would reveal the results of chemosensitivity in quantitative values will a valid guide to antimicrobic chemotherapy be possible. Expressing chemosensitive bacteria directly in values of minimum inhibiting concentrations would evaluate the pharmokinetic action of single chemotherapeutical agents in relation to infective organ or apparatus pathologies which limits the practical significance of posology. Unfortunately, the collaboration between the clinical bacteriologist and the chemoterapist is still a long way off because of technical and laboratory difficulties delineating the pharmokinetic aspects in the use of the many chemoterapeutical agents in man.
在对药敏试验作为治疗指南的有效性进行一些一般性考虑之后，描述并分析了三种方法。通过以下方法测试细菌对抗菌药物的化学敏感性：扩散法、稀释法和自动化方法。只有当转化为能以定量值显示化学敏感性结果的常规实验室方法时，才有可能成为抗菌化疗的有效指南。直接以最低抑菌浓度值来表示化学敏感细菌，将评估单一化疗药物相对于感染器官或器械病变的药代动力学作用，这限制了剂量学的实际意义。不幸的是，由于在人体中使用多种化疗药物时，在描述药代动力学方面存在技术和实验室困难，临床细菌学家和化疗师之间的合作仍有很长的路要走。
