Metzger K
Arzneimittelforschung. 1977 Feb;27(2A):286-8.
The therapy of bacterial infections is considered against the background of the relations existing within the system bacteria-man-chemical substance. The experimental conditions and the difficulties are discussed which are encountered in the determination of in vitro values and their transfer into therapy. On this background the basic equation of chemotherapy is discussed. The factors are given which reduce the strict validity of this basic equation and lead to the introduction of a safety factor when making a dose proposal.
细菌感染的治疗是在细菌-人-化学物质系统中存在的关系背景下进行考虑的。文中讨论了在确定体外值及其转化为治疗方法时所遇到的实验条件和困难。在此背景下，对化疗的基本方程进行了讨论。给出了降低该基本方程严格有效性并导致在提出剂量建议时引入安全系数的因素。
