Soldin S J, Fingold D R, Fenje P C, Mahon W A
Ther Drug Monit. 1979;1(3):371-9. doi: 10.1097/00007691-197901030-00010.
A rapid and reliable micro procedure for the high pressure liquid chromatographic analysis of cimetidine. N"-cyano-N-methyl-N'-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine, in serum or plasma is described. The percentage analytical recovery of cimetidine and internal standard (beta-hydroxypropyl-theophylline) was 65 and 99%, respectively. The between-day precision of the method at cimetidine serum concentrations of 2,000, 1,000, and 500 microgram/liter yielded coefficients of variation of 10.6, 11.5, and 10.6%, respectively. The method has been used in preliminary studies to determine the serum concentrations in patients receiving the drug by both the oral and intravenous route.
一种用于西咪替丁高效液相色谱分析的快速可靠的微量方法。描述了在血清或血浆中分析N"-氰基-N-甲基-N'-[2-[[(5-甲基-1H-咪唑-4-基)甲基]硫代]乙基]胍的方法。西咪替丁和内标（β-羟丙基茶碱）的分析回收率分别为65%和99%。该方法在西咪替丁血清浓度为2000、1000和500微克/升时的日间精密度分别产生变异系数为10.6%、11.5%和10.6%。该方法已用于初步研究，以测定通过口服和静脉途径接受该药物的患者的血清浓度。
