el-Haieg M O, Enein M M, Mustafa M A, el-Khodary M I, Refaat M A, Ibrahim I A, Abul-Fadl M A
Egypt J Bilharz. 1978;5(1-2):19-28.
Determination of serum enzymatic activities in hepatosplenic bilharziasis (H.S.B.) were conducted in 100 bilharzial patients, in different stages and 30 controls SGot, SGPT, ALK pH, ALD and SLDH with its both fractions heat stable and labile.). Early elevation of serum enzymatic activities of SGOT, SGPT and SALK. pH, may be considered as a sensitive parameter for functional changes in H.S.B. rather than other conventional liver function tests. The elevated enzymic activity of total LDH in this study was associated with elevation in its both fractions. In particular, the changes in the total activity was in parallel with that of its heat labile fraction. The latter may be considered as a confirmatory test for marked deterioration of liver functions in H.S.B. The changes in the heat stable fraction was inconstant and may be attributed to extrahepatic bilharzial dissimilation. Significantly high serum enzymatic activity of SALD was found in cases of H.S.B. particularly those showing striking muscle wasting.
对100例处于不同阶段的血吸虫病患者及30名对照者进行了肝脾血吸虫病（H.S.B.）血清酶活性的测定（测定了谷草转氨酶、谷丙转氨酶、碱性磷酸酶、醛缩酶和乳酸脱氢酶及其热稳定和热不稳定两个组分）。谷草转氨酶、谷丙转氨酶和碱性磷酸酶血清酶活性的早期升高，可被视为肝脾血吸虫病功能变化的一个敏感参数，而非其他传统肝功能检查。本研究中总乳酸脱氢酶的酶活性升高与其两个组分的升高相关。特别是，总活性的变化与其热不稳定组分的变化平行。后者可被视为肝脾血吸虫病肝功能显著恶化的一项确诊试验。热稳定组分的变化不稳定，可能归因于肝外血吸虫异化作用。在肝脾血吸虫病病例中发现醛缩酶血清酶活性显著升高，尤其是那些出现明显肌肉萎缩的病例。
