利用L-阿拉伯糖生产表型无差向异构酶的酵母。
Production of phenotypically epimeraseless yeast by L-arabinose.
作者信息
Azam F, Kuo S C, Cirillo V P
出版信息
J Bacteriol. 1971 Jun;106(3):915-9. doi: 10.1128/jb.106.3.915-919.1971.
Abstract
The previous report from this laboratory that l-arabinose is a gratuitous inducer of the galactose transport system has been found to be an artefact resulting from the combination of galactose contamination of commercial samples of l-arabinose and inhibition by l-arabinose of galactose metabolism by inactivation of uridine-diphosphate-glucose-4-epimerase. As a result of l-arabinose inhibition of the metabolism of the contaminating galactose, galactose itself serves as a gratuitous inducer, producing phenotypically epimeraseless yeast.
摘要
该实验室之前的报告称，L-阿拉伯糖是半乳糖转运系统的 gratuitous 诱导剂，现已发现这是一种人为现象，是由 L-阿拉伯糖商业样品中的半乳糖污染以及 L-阿拉伯糖通过使尿苷二磷酸葡萄糖-4-表异构酶失活而抑制半乳糖代谢共同导致的。由于 L-阿拉伯糖抑制了污染的半乳糖的代谢，半乳糖本身就充当了 gratuitous 诱导剂，产生表型上无表异构酶的酵母。
相似文献
1
Production of phenotypically epimeraseless yeast by L-arabinose.利用L-阿拉伯糖生产表型无差向异构酶的酵母。
J Bacteriol. 1971 Jun;106(3):915-9. doi: 10.1128/jb.106.3.915-919.1971.
2
L-Arabinose is not a gratuitous inducer of alpha-galactosidase from Saccharomyces carlsbergensis.L-阿拉伯糖不是卡尔斯伯酵母α-半乳糖苷酶的诱导剂。
Arch Microbiol. 1984 Jan;137(1):10-3. doi: 10.1007/BF00425800.
3
Galactose transport in Saccharomyces cerevisiae. II. Characteristics of galactose uptake and exchange in galactokinaseless cells.酿酒酵母中的半乳糖转运。II. 无半乳糖激酶细胞中半乳糖摄取和交换的特征。
J Bacteriol. 1970 Sep;103(3):671-8. doi: 10.1128/jb.103.3.671-678.1970.
4
D-Fucose as a gratuitous inducer of the L-arabinose operon in strains of Escherichia coli B-r mutant in gene araC.D-岩藻糖作为阿拉伯糖操纵子在大肠杆菌B-r araC基因突变株中的 gratuitous诱导剂 。 （注：这里“gratuitous”不太明确准确意思，可根据具体专业背景进一步确认准确含义来完善译文表述）
J Bacteriol. 1971 Jul;107(1):79-86. doi: 10.1128/jb.107.1.79-86.1971.
5
Concerted reduction of yeast uridine diphosphate galactose 4-epimerase.酵母尿苷二磷酸半乳糖4-表异构酶的协同降低
Biochemistry. 1971 Apr 27;10(9):1545-51. doi: 10.1021/bi00785a006.
6
Galactose transport in Saccharomyces cerevisiae. 3. Characteristics of galactose uptake in transferaseless cells: evidence against transport-associated phosphorylation.酿酒酵母中的半乳糖转运。3. 无转糖基酶细胞中半乳糖摄取的特性：反对转运相关磷酸化的证据
J Bacteriol. 1970 Sep;103(3):679-85. doi: 10.1128/jb.103.3.679-685.1970.
7
Galactose transport in Saccharomyces cerevisiae. I. Nonmetabolized sugars as substrates and inducers of the galactose transport system.酿酒酵母中的半乳糖转运。I. 非代谢性糖作为半乳糖转运系统的底物和诱导剂。
J Bacteriol. 1968 May;95(5):1727-31. doi: 10.1128/jb.95.5.1727-1731.1968.
8
Specific tritium labeling of uridine diphosphogalactose 4-epimerase by D-(1- 3 H) galactose.用D-（1-³H）半乳糖对尿苷二磷酸半乳糖4-差向异构酶进行特异性氚标记。
Biochemistry. 1972 Jan 4;11(1):36-40. doi: 10.1021/bi00751a007.
9
Hyperinducibility as a result of mutation in structural genes and self-catabolite repression in the ara operon.由于结构基因突变导致的超诱导性以及阿拉伯糖操纵子中的自我分解代谢物阻遏。
J Bacteriol. 1971 Jul;107(1):34-52. doi: 10.1128/jb.107.1.34-52.1971.
10
The reductive inactivation of UDPgalactose-4-epimerase from yeast and E. coli.来自酵母和大肠杆菌的UDP半乳糖-4-表异构酶的还原失活
Proc Natl Acad Sci U S A. 1970 Apr;65(4):1113-9. doi: 10.1073/pnas.65.4.1113.
引用本文的文献
1
L-Arabinose is not a gratuitous inducer of alpha-galactosidase from Saccharomyces carlsbergensis.L-阿拉伯糖不是卡尔斯伯酵母α-半乳糖苷酶的诱导剂。
Arch Microbiol. 1984 Jan;137(1):10-3. doi: 10.1007/BF00425800.
2
Inhibition by 2-deoxy-D-glucose of synthesis of glycoprotein enzymes by protoplasts of Saccharomyces: relation to inhibition of sugar uptake and metabolism.2-脱氧-D-葡萄糖对酿酒酵母原生质体合成糖蛋白酶的抑制作用：与糖摄取和代谢抑制的关系。
J Bacteriol. 1972 Aug;111(2):419-29. doi: 10.1128/jb.111.2.419-429.1972.
本文引用的文献
1
HEREDITARY DEFECTS IN GALACTOSE METABOLISM IN ESCHERICHIA COLI MUTANTS, I. DETERMINATION OF ENZYME ACTIVITIES.大肠杆菌突变体中半乳糖代谢的遗传性缺陷，I. 酶活性的测定
Proc Natl Acad Sci U S A. 1959 Dec;45(12):1776-86. doi: 10.1073/pnas.45.12.1776.
2
A sensitive assay for galactokinase in Escherichia coli.一种用于检测大肠杆菌中半乳糖激酶的灵敏测定法。
Anal Biochem. 1962 Jun;3:498-513. doi: 10.1016/0003-2697(62)90083-0.
3
ENZYMATIC EXPRESSION AND GENETIC LINKAGE OF GENES CONTROLLING GALACTOSE UTILIZATION IN SACCHAROMYCES.酿酒酵母中控制半乳糖利用的基因的酶表达与遗传连锁
Genetics. 1964 May;49(5):837-44. doi: 10.1093/genetics/49.5.837.
4
THE PURIFICATION AND PROPERTIES OF YEAST GALACTOKINASE.
J Biol Chem. 1964 Jan;239:50-3.
5
[REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF THE ENZYMES OF GALACTOSE METABOLISM IN ESCHERICHIA COLI K 12. I. THE INDUCED BIOSYNTHESIS OF GALACTOKINASE AND THE SIMULTANEOUS INDUCTION OF THE ENZYMATIC SEQUENCE].[大肠杆菌K12中半乳糖代谢酶生物合成的调控机制。I. 半乳糖激酶的诱导生物合成及酶序列的同步诱导]
J Mol Biol. 1963 Aug;7:164-82. doi: 10.1016/s0022-2836(63)80044-3.
6
Studies on uridine-diphosphate-glucose.尿苷二磷酸葡萄糖的研究。
Biochem J. 1952 Jun;51(3):426-30. doi: 10.1042/bj0510426.
7
Regulation of genes controlling synthesis of the galactose pathway enzymes in yeast.酵母中控制半乳糖途径酶合成的基因调控
Genetics. 1966 Sep;54(3):911-6. doi: 10.1093/genetics/54.3.911.
8
Galactose transport in Saccharomyces cerevisiae. I. Nonmetabolized sugars as substrates and inducers of the galactose transport system.酿酒酵母中的半乳糖转运。I. 非代谢性糖作为半乳糖转运系统的底物和诱导剂。
J Bacteriol. 1968 May;95(5):1727-31. doi: 10.1128/jb.95.5.1727-1731.1968.
9
Role of the galactose transport system in the establishment of endogenous induction of the galactose operon in Escherichia coli.半乳糖转运系统在大肠杆菌中半乳糖操纵子内源性诱导建立过程中的作用。
J Mol Biol. 1967 Mar 14;24(2):213-23. doi: 10.1016/0022-2836(67)90327-0.
10
Reversible changes of ordered polypeptide structures in oxidized and reduced epimerase.氧化型和还原型差向异构酶中有序多肽结构的可逆变化。
Proc Natl Acad Sci U S A. 1968 Oct;61(2):629-35. doi: 10.1073/pnas.61.2.629.
Zotero 插件