Engel R, Halberg F, Nelson W, Bartter F C
Int J Chronobiol. 1979;6(3):163-78.
Autorhythmometry of blood pressure by an individual over an age-span of 67 to 72 years showed a strong circadian rhythm superimposed upon significant circaseptan and circannual rhythms. Automatic BP monitoring with an Arteriosonde throughout 24-hour spans on 4 separate occasions, before and during treatment, also indicated a prominent circadian BP rhythm and a treatment-related reduction in circadian mesor. The concept of a blood pressure mesor reference for the antimesor-hypertensive treatment constitutes a valuable guideline in the control of "familial" mesor-hypertension.
67至72岁个体的血压自节律测量显示，在显著的近一周节律和近一年节律之上叠加有强烈的昼夜节律。在治疗前和治疗期间，使用动脉超声仪在4个不同时间段进行24小时连续自动血压监测，也表明存在显著的昼夜血压节律以及与治疗相关的昼夜均值降低。抗均值高血压治疗的血压均值参考概念是控制“家族性”均值高血压的一项有价值的指导原则。
