Bartter F C, Delea C S, Baker W, Halberg F, Lee J K
Chronobiologia. 1976 Jul-Sep;3(3):199-213.
An elevation of systolic and diastolic bloodpressure to values regarded as abnormal ones on the basis of conventional criteria was recognized by self-measurement. For both systolic and diastolic blood pressure, the overall means adjusted for rhythms, the so-called mesors, also were elevated in the light of their response to treatment: these mesors were found to be lowered with statistical significance when values during treatment were compared by an objective test with values measured before treatment. Individualized rhythmometry quantitatively characterizes a predictalbe portion of the variability in human blood pressure and tests for the statistical significance of changes in blood pressure as a function of the treatment and also as a function of the circadian timing of such treatment. The case report thus illustrates an individualized chronotherapy of systolic and diastolic mesor-hypertension, diagnosed retrospectively from the tested effect of hydrochlorothiazide. In the case reported, and perhaps routinely, computer-analyzed self-measurements can serve 1) to prescribe the right kind and amount with the right timing, for a given therapy, and 2) for diagnosis and prevention as well (Meyer et al.; Halberg et al.).
通过自我测量发现收缩压和舒张压升高至基于传统标准被视为异常的值。对于收缩压和舒张压，根据它们对治疗的反应，经节律调整后的总体均值（即所谓的中值）也升高了：当通过客观测试将治疗期间的值与治疗前测量的值进行比较时，发现这些中值有统计学意义的降低。个体化节律测量法定量地描述了人类血压变异性中可预测的部分，并测试血压变化作为治疗函数以及作为这种治疗的昼夜时间函数的统计学意义。该病例报告因此说明了收缩压和舒张压中值高血压的个体化时间疗法，这是根据氢氯噻嗪的测试效果进行回顾性诊断的。在所报告的病例中，也许是常规地，计算机分析的自我测量可以用于1）为给定的治疗在正确的时间开出正确种类和剂量的药物，以及2）也用于诊断和预防（迈耶等人；哈尔伯格等人）。
