Rovere A A, Raynald A C, Berman J M, San Román A, García C A
Acta Physiol Lat Am. 1978;28(2-3):133-9.
Local blood flow was measured in renal cortex (1 mm below cortical surface) by means of the hydrogen clearance method in urethanized rats. Recording of blood pressure from femoral artery was performed. Crotalus durissus terrificus venom injection (one mg/kg i.v.) significantly decreased cortical blood flow at 10 min, without a significant arterial pressure modification. Posterior injection of mannitol 200 mg induced a significant increase in cortical blood flow, although initial values were not reached. Electron microscopy showed thromboses in the glomerular capillaries 35 minutes after venom injection. It is suggested that the precocious effect of this venom on renal cortical blood flow may be instrumental in the development of the renal acute insufficiency induced by Crotalus durissus terrificus venom.
采用氢清除法在经乌拉坦麻醉的大鼠肾皮质（皮质表面以下1毫米处）测量局部血流。同时记录股动脉血压。静脉注射1毫克/千克的三色矛头蝮蛇毒，10分钟时皮质血流显著降低，而动脉压无显著改变。随后注射200毫克甘露醇可使皮质血流显著增加，尽管未达到初始值。电子显微镜显示，注射蛇毒35分钟后肾小球毛细血管内有血栓形成。提示该蛇毒对肾皮质血流的早熟效应可能在三色矛头蝮蛇毒所致肾急性功能不全的发生中起作用。
