Rovere A A, Scremin O U
Acta Physiol Lat Am. 1977;27(2):80-6.
Experiments were conducted on rats to investigate the acute effects on renal cortical blood flow and cortical autoregulation caused by intravenous administration of hypertonic solutions of sodium chloride or glucose. Local blood flow was measured in renal cortex (at 1 mm below cortical surface) by means of the hydrogen clearance method in urethanized rats. Recording of blood pressure from femoral artery was performed. In control group, renal cortical vascular resistance (R.C.V.R.)--arterial pressure relationships demonstrated typical autoregulation. An increase in plasma osmolarity of approximately 5.90%, induced by glucose, did not affect autoregulation. An increase in plasma osmolarity of approximately 4.43%, induced by NaCl, avoided autoregulation and the resistance-arterial pressure relationships became passive in appearance. In addition, NaCl administration was associated with an increase in cortical blood flow. It is suggested that in the presence of a low increment in plasma osmolarity, the sodium ion rather than the osmolarity itself, is the factor that influences cortical blood flow autoregulation in the rat.
对大鼠进行实验，以研究静脉注射高渗氯化钠或葡萄糖溶液对肾皮质血流和皮质自身调节的急性影响。在乌拉坦麻醉的大鼠中，通过氢清除法测量肾皮质（皮质表面以下1毫米处）的局部血流。记录股动脉血压。在对照组中，肾皮质血管阻力（R.C.V.R.）与动脉压的关系显示出典型的自身调节。葡萄糖引起的血浆渗透压约升高5.90%，并不影响自身调节。氯化钠引起的血浆渗透压约升高4.43%，破坏了自身调节，阻力与动脉压的关系在外观上变得被动。此外，注射氯化钠与皮质血流增加有关。有人提出，在血浆渗透压轻度升高的情况下，影响大鼠皮质血流自身调节的因素是钠离子，而不是渗透压本身。
