Lavine J B, Binder P S, Wickham M G
Ann Ophthalmol. 1979 Oct;11(10):1517-28.
The effects of various intraocular antibiotics and preservatives on the rabbit corneal endothelium were evaluated using vital staining, light, scanning, and transmission electron microscopy after topical application of the drugs and up to 2 days following anterior chamber injection. Benzalkonium chloride consistently produced the most severe and probably irreversible damage. Some changes which persisted for 2 days were found with methicillin. Gentamicin produced a moderate amount of cellular edema which disappeared after 2 days. Minimal changes were produced by dexamethasone and amphotericin B. Although these results should not be directly interpolated to the human situation, the face that some of these agents did produce changes in the rabbit corneal endothelium, which is well known to be heartier than human endothelium, indicates that caution should be taken when one considers injecting antibiotics intraocularly.
在局部应用药物后以及前房注射后长达2天的时间里，通过活体染色、光学显微镜、扫描电子显微镜和透射电子显微镜，评估了各种眼内抗生素和防腐剂对兔角膜内皮的影响。苯扎氯铵始终会造成最严重且可能不可逆的损伤。甲氧西林会导致一些持续2天的变化。庆大霉素会引起中度细胞水肿，2天后消失。地塞米松和两性霉素B产生的变化最小。尽管这些结果不应直接套用到人类情况，但这些药物中的一些确实对兔角膜内皮产生了变化，而兔角膜内皮比人类内皮更坚韧，这表明在考虑眼内注射抗生素时应谨慎。
