亲同种细胞抗体固定位点的特异性
Specificity of fixation loci for homocytotropic antibodies.
作者信息
Battisto J R, Budman D, Freedman R
出版信息
J Exp Med. 1971 Aug 1;134(2):381-94. doi: 10.1084/jem.134.2.381.
Abstract
The heat-stable, homocytotropic antibody synthesized by guinea pigs to highly purified dextran has been studied by passive cutaneous anaphylaxis (PCA). Antibody arising in single guinea pigs was found to give PCA in some homologous recipients but not in others. Data are presented which indicate that the antibodies are bound in the skin of some animals to a greater degree than in that of others. This suggests some type of variability, perhaps allotypic, in the Fc portion of these immunoglobulins which relates to specificities of the loci where Fc becomes fixed in skin.
摘要
通过被动皮肤过敏反应（PCA）研究了豚鼠针对高度纯化的右旋糖酐合成的热稳定、亲同种细胞抗体。发现单只豚鼠产生的抗体在一些同源受体中能引发PCA反应，但在其他受体中则不能。所呈现的数据表明，这些抗体在某些动物皮肤中的结合程度高于其他动物。这表明这些免疫球蛋白的Fc部分存在某种类型的变异性，可能是同种异型的，这与Fc在皮肤中固定的位点特异性有关。
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