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分离抗体的个体抗原特异性

Individual Antigenic Specificity of Isolated Antibodies.

作者信息

Kunkel H G, Mannik M, Williams R C

出版信息

Science. 1963 Jun 14;140(3572):1218-9. doi: 10.1126/science.140.3572.1218.

DOI:10.1126/science.140.3572.1218
PMID:17837506
Abstract

Antisera produced against certain isolated human antibodies showed clear antigenic differences between these antibodies. Individual antigenic specificity was demonstrated for two anti-A antibodies, one anti-dextran, and one anti-levan antibody. Failure to produce specific antisera in other instances appeared to be correlated with a greater heterogeneity of the antibody population used as antigen.

摘要

针对某些分离出的人抗体产生的抗血清显示出这些抗体之间明显的抗原差异。证明了两种抗A抗体、一种抗右旋糖酐抗体和一种抗左聚糖抗体具有各自的抗原特异性。在其他情况下未能产生特异性抗血清似乎与用作抗原的抗体群体具有更大的异质性有关。

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