猫胰腺在迷走神经刺激下的汁液分泌。
The flow of juice from the pancreatic gland of the cat in response to vagal stimulation.
作者信息
Lenninger S, Ohlin P
出版信息
J Physiol. 1971 Jul;216(2):303-18. doi: 10.1113/jphysiol.1971.sp009526.
Abstract
- Stimulation of the vagus nerve of the cat causes a pancreatic secretion in most animals. The volume of the secretion is about 20% of the maximal response of the gland to exogenous secretin.2. Maximal secretory effect of vagal stimulation is obtained with frequencies between 8 and 15 c/s.3. The effect of the nerve stimulation is direct on the pancreas and not mediated by gastro-intestinal hormones.4. The secretion of water in response to vagal stimulation is not depressed by anticholinergic agents in doses which profoundly depress the secretion of enzymes.5. The secretion of water in response to submaximal vagal stimulation is not increased by eserinization of the gland, whereas the output of proteins is strongly augmented by this procedure.6. The significance of the finding that the watery and enzymic secretion can be dissociated pharmacologically is discussed.
摘要
刺激猫的迷走神经会在大多数动物中引起胰腺分泌。分泌量约为腺体对外源性促胰液素最大反应的20%。
迷走神经刺激的最大分泌效应在频率为8至15次/秒时获得。
神经刺激对胰腺的作用是直接的，并非由胃肠激素介导。
抗胆碱能药物在能显著抑制酶分泌的剂量下，并不会抑制因迷走神经刺激而产生的水分泌。
腺体经毒扁豆碱处理后，对次最大迷走神经刺激的水分泌量不会增加，而蛋白质的分泌量会因该处理而显著增加。
对水分泌和酶分泌在药理学上可分离这一发现的意义进行了讨论。
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