β-胍基丙酸与γ-氨基丁酸在小龙虾肌纤维上的竞争性相互作用。
Competitive interaction of beta-guanidino propionic acid and gamma-aminobutyric acid on the muscle fibre of the crayfish.
作者信息
Feltz A
出版信息
J Physiol. 1971 Jul;216(2):391-401. doi: 10.1113/jphysiol.1971.sp009531.
Abstract
- The interaction of beta-guanidino propionic acid and gamma-aminobutyric acid has been investigated on the crayfish muscle by measurement of the membrane conductance.2. The increase in membrane conductance produced by GABA is depressed by beta-guanidino propionic acid. This antagonist acts in a competitive way as shown by the shift of log dose-response curves and by the results of tests for competitive interaction (method of Schild (1947); Lineweaver and Burk's plot).3. Perfusion of GABA was shown to induce a receptor desensitization. As a consequence, the slope of the dose-response curve plotted in Hill's co-ordinates increases when care is taken to minimize this phenomenon. The significance of this slope for establishing the real number of GABA molecules binding with the GABA receptor is discussed.
摘要
通过测量膜电导，研究了β-胍基丙酸与γ-氨基丁酸在小龙虾肌肉上的相互作用。
β-胍基丙酸可抑制γ-氨基丁酸引起的膜电导增加。这种拮抗剂以竞争性方式起作用，对数剂量-反应曲线的移动以及竞争性相互作用测试结果（Schild（1947年）方法；Lineweaver和Burk图）表明了这一点。
已证明灌注γ-氨基丁酸会诱导受体脱敏。因此，当注意尽量减少这种现象时，以希尔坐标绘制的剂量-反应曲线的斜率会增加。讨论了该斜率对于确定与γ-氨基丁酸受体结合的γ-氨基丁酸分子实际数量的意义。
相似文献
1
Competitive interaction of beta-guanidino propionic acid and gamma-aminobutyric acid on the muscle fibre of the crayfish.β-胍基丙酸与γ-氨基丁酸在小龙虾肌纤维上的竞争性相互作用。
J Physiol. 1971 Jul;216(2):391-401. doi: 10.1113/jphysiol.1971.sp009531.
2
A study of the action of picrotoxin on the inhibitory neuromuscular junction of the crayfish.关于印防己毒素对小龙虾抑制性神经肌肉接头作用的研究。
J Physiol. 1969 Nov;205(2):377-91. doi: 10.1113/jphysiol.1969.sp008972.
3
The structure-activity relationship for GABA and related compounds in the crayfish muscle.小龙虾肌肉中γ-氨基丁酸及相关化合物的构效关系。
Neuropharmacology. 1975 Sep;14(9):627-34. doi: 10.1016/0028-3908(75)90085-4.
4
Four types of GABA receptors in crayfish leg muscles characterized by desensitization and specific antagonist.小龙虾腿部肌肉中四种GABA受体的脱敏特性及特异性拮抗剂研究
Pflugers Arch. 1976 Aug 24;364(3):217-22. doi: 10.1007/BF00581758.
5
A comparison of the effects of GABA and imidazoleacetic acid on the membrane conductance of lobster muscle fibres.γ-氨基丁酸和咪唑乙酸对龙虾肌肉纤维膜电导影响的比较。
Brain Res. 1974 Oct 18;79(2):306-10. doi: 10.1016/0006-8993(74)90422-3.
6
On the pharmacology of the gamma-aminobutyric acid receptors on the cuneo-thalamic relay cells of the cat.关于猫楔丘脑中继细胞上γ-氨基丁酸受体的药理学研究
Br J Pharmacol. 1973 Jul;48(3):369-86. doi: 10.1111/j.1476-5381.1973.tb08346.x.
7
Desensitization of gamma aminobutyric acid (GABA) receptors in muscle fibers of the crab Cancer borealis.北方黄道蟹肌肉纤维中γ-氨基丁酸（GABA）受体的脱敏作用
J Gen Physiol. 1970 Jul;56(1):33-45. doi: 10.1085/jgp.56.1.33.
8
The GABA dose/conductance relationship on lobster muscle.龙虾肌肉上的γ-氨基丁酸剂量/电导关系。
J Physiol (Paris). 1979;75(6):645-9.
9
Effect of tetramethylenedisulphotetramine on the membrane conductance increase produced by gamma-amino-butyric acid at the crab neuromuscular junction.四亚甲基二砜四胺对蟹神经肌肉接头处γ-氨基丁酸引起的膜电导增加的影响。
Br J Pharmacol. 1975 Apr;53(4):598-9. doi: 10.1111/j.1476-5381.1975.tb07401.x.
10
On the pharmacology of the glycine receptors on the cuneo-thalamic relay cells in the cat.关于猫楔束-丘脑中继细胞甘氨酸受体的药理学研究。
Br J Pharmacol. 1973 Jul;48(3):387-95. doi: 10.1111/j.1476-5381.1973.tb08347.x.
引用本文的文献
1
Paradoxical Increase in Body Mass Induced by Beta-Guanidinopropionic Acid in Juvenile Spontaneously Hypertensive Rats.β-胍基丙酸诱导幼年自发性高血压大鼠体重反常增加
Cureus. 2021 Nov 9;13(11):e19394. doi: 10.7759/cureus.19394. eCollection 2021 Nov.
2
Fourth gaddum memorial lecture, school of pharmacy, university of london, january 1973.第四届加德姆纪念讲座，伦敦大学药学院，1973年1月
Br J Pharmacol. 1973 Jul;48(3):475-95. doi: 10.1111/j.1476-5381.1973.tb08355.x.
3
Inhibitory synaptic channels activated by gamma-aminobutyric acid (GABA) in crayfish muscle.小龙虾肌肉中由γ-氨基丁酸（GABA）激活的抑制性突触通道。
Pflugers Arch. 1980 Sep;387(2):143-51. doi: 10.1007/BF00584265.
4
Comparison of the effects of ethylenediamine analogues and gamma-aminobutyric acid on cortical and pallidal neurones.乙二胺类似物和γ-氨基丁酸对皮质和苍白球神经元作用的比较。
Br J Pharmacol. 1982 Jan;75(1):93-9. doi: 10.1111/j.1476-5381.1982.tb08761.x.
5
Structure-activity studies on the potentiation of benzodiazepine receptor binding by ethylenediamine analogues and derivatives.乙二胺类似物和衍生物对苯二氮䓬受体结合增强作用的构效关系研究
Br J Pharmacol. 1983 Aug;79(4):973-7. doi: 10.1111/j.1476-5381.1983.tb10543.x.
6
Effects of glycine on the crayfish neuromuscular junction. I. Glycine-operated inhibitory postsynaptic channels and a glycine-effected decrease in membrane conductance.甘氨酸对小龙虾神经肌肉接头的作用。I. 甘氨酸操纵的抑制性突触后通道及甘氨酸引起的膜电导降低。
Pflugers Arch. 1983 Apr;397(2):121-7. doi: 10.1007/BF00582049.
7
Closing of membrane channels effected by gamma-amino-butyric acid (GABA) in crayfish muscle.γ-氨基丁酸（GABA）对小龙虾肌肉中膜通道的关闭作用
Pflugers Arch. 1980 Sep;387(2):153-60. doi: 10.1007/BF00584266.
8
On the pharmacology of the gamma-aminobutyric acid receptors on the cuneo-thalamic relay cells of the cat.关于猫楔丘脑中继细胞上γ-氨基丁酸受体的药理学研究
Br J Pharmacol. 1973 Jul;48(3):369-86. doi: 10.1111/j.1476-5381.1973.tb08346.x.
9
Analysis of hyperpolarizations induced by glutamate and acetylcholine on Onchidium neurones.谷氨酸和乙酰胆碱对石磺神经元诱导的超极化分析。
J Physiol. 1974 Dec;243(2):321-41. doi: 10.1113/jphysiol.1974.sp010756.
10
The pharmacology and ionic dependency of amino acid responses in the frog spinal cord.青蛙脊髓中氨基酸反应的药理学及离子依赖性
J Physiol. 1973 Jan;228(2):259-77. doi: 10.1113/jphysiol.1973.sp010085.
本文引用的文献
1
PRESYNAPTIC AND POSTSYNAPTIC EFFECTS OF INHIBITORY DRUGS ON THE CRAYFISH NEUROMUSCULAR JUNCTION.抑制性药物对小龙虾神经肌肉接头的突触前和突触后作用
Pflugers Arch Gesamte Physiol Menschen Tiere. 1965 Mar 18;283:104-18. doi: 10.1007/BF00363182.
2
LOCALIZED ACTION OF GAMMA-AMINOBUTYRIC ACID ON THE CRAYFISH MUSCLE.γ-氨基丁酸对小龙虾肌肉的局部作用
J Physiol. 1965 Mar;177(2):225-38. doi: 10.1113/jphysiol.1965.sp007588.
3
FURTHER OBSERVATIONS ON THE DISTRIBUTION OF ACTYLCHOLINE-REACTIVE SITES IN SKELETAL MUSCLE.关于骨骼肌中乙酰胆碱反应位点分布的进一步观察
J Physiol. 1964 Mar;170(2):379-88. doi: 10.1113/jphysiol.1964.sp007338.
4
GAMMA-AMINOBUTYRIC ACID AND OTHER BLOCKING COMPOUNDS IN CRUSTACEA. III. THEIR RELATIVE CONCENTRATIONS IN SEPARATED MOTOR AND INHIBITORY AXONS.甲壳纲动物中的γ-氨基丁酸及其他阻断化合物。III. 它们在分离出的运动轴突和抑制性轴突中的相对浓度。
J Neurophysiol. 1963 Sep;26:739-51. doi: 10.1152/jn.1963.26.5.739.
5
Presynaptic nature of neuromuscular depression.神经肌肉抑制的突触前性质
Jpn J Physiol. 1962 Dec 15;12:573-84. doi: 10.2170/jjphysiol.12.573.
6
Presynaptic inhibition at the crayfish neuromuscular junction.小龙虾神经肌肉接头处的突触前抑制。
J Physiol. 1961 Mar;155(3):543-62. doi: 10.1113/jphysiol.1961.sp006646.
7
The blocking effect of gamma-aminobutyric acid (GABA) and the action of related compounds on single nerve cells.γ-氨基丁酸（GABA）的阻断作用及相关化合物对单个神经细胞的作用。
J Neurochem. 1959 Apr;4(1):19-30. doi: 10.1111/j.1471-4159.1959.tb13170.x.
8
Some quantitative uses of drug antagonists.药物拮抗剂的一些定量应用。
Br J Pharmacol Chemother. 1959 Mar;14(1):48-58. doi: 10.1111/j.1476-5381.1959.tb00928.x.
9
Membrane permeability change during inhibitory transmitter action in crustacean muscle.甲壳类肌肉中抑制性递质作用期间的膜通透性变化
J Physiol. 1958 Nov 10;144(1):176-91. doi: 10.1113/jphysiol.1958.sp006094.
10
Mechanism of gamma aminobutyric acid (GABA) action and its relation to synaptic inhibition.γ-氨基丁酸（GABA）的作用机制及其与突触抑制的关系。
J Neurophysiol. 1958 Nov;21(6):589-610. doi: 10.1152/jn.1958.21.6.589.
Zotero 插件