蜗牛神经元电压钳制期间的两种快速瞬态电流成分。
Two fast transient current components during voltage clamp on snail neurons.
作者信息
Neher E
出版信息
J Gen Physiol. 1971 Jul;58(1):36-53. doi: 10.1085/jgp.58.1.36.
Abstract
Voltage clamp currents from medium sized ganglion cells of Helix pomatia have a fast transient outward current component in addition to the usually observed inward and outward currents. This component is inactivated at normal resting potential. The current, which is carried by K+ ions, may surpass leakage currents by a factor of 100 after inactivation has been removed by hyperpolarizing conditioning pulses. Its kinetics are similar to those of the inward current, except that it has a longer time constant of inactivation. It has a threshold close to resting potential. This additional component is also present in giant cells, where however, it is less prominent. Pacemaker activity is controlled by this current. It was found that inward currents have a slow inactivating process in addition to a fast, Hodgkin-Huxley type inactivation. The time constants of the slow process are similar to those of slow outward current inactivation.
摘要
除了通常观察到的内向和外向电流外，苹果蜗牛中等大小神经节细胞的电压钳电流还有一个快速瞬态外向电流成分。该成分在正常静息电位下失活。由K+离子携带的电流，在通过超极化调节脉冲消除失活后，可能比漏电流大100倍。其动力学与内向电流相似，只是失活的时间常数更长。它的阈值接近静息电位。这种额外的成分在巨细胞中也存在，不过在巨细胞中不太明显。起搏活动受该电流控制。研究发现，内向电流除了具有快速的霍奇金-赫胥黎型失活外，还有一个缓慢的失活过程。缓慢过程的时间常数与缓慢外向电流失活的时间常数相似。
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