Greene C E, Barsanti J A, Jones B D
Cornell Vet. 1977 Jan;67(1):29-49.
An outbreak of chronic liver disease was investigated in a kennel of dogs. Anorexia, depression, polyuria, polydipsia, icterus and a terminal hemorrhagic diathesis were noted in clinically affected dogs. Thrombocytopenia, hypofibrinogenemia, elevated fibrinogen degradation products and prolonged activated partial thrombosplastin times (PTT) and one-stage prothrombin times (PT) were associated with the hemorrhagic crisis. Aflatoxicosis was confirmed by the presence of significant levels of aflatoxicosis was confirmed by the presence of significant levels of aflatoxin B in the commercial dog food being fed. A subacute hepatitis was found on necropsy. Disseminated intravascular coagulation was suspected as the cause of the hemorrhage in these cases and treatment was instituted.
在一个犬舍中对一场慢性肝病暴发进行了调查。临床患病犬出现厌食、抑郁、多尿、多饮、黄疸以及终末期出血素质。血小板减少、纤维蛋白原血症、纤维蛋白原降解产物升高以及活化部分凝血活酶时间（PTT）和一期凝血酶原时间（PT）延长与出血危机相关。通过所喂食的商业犬粮中存在显著水平的黄曲霉毒素B证实了黄曲霉毒素中毒。尸检发现亚急性肝炎。怀疑这些病例中的出血原因是弥散性血管内凝血并开展了治疗。
