Dewhurst E, Cue S, Crawford E, Papasouliotis K
Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford, Bristol BS40 5DU.
J Small Anim Pract. 2008 Jul;49(7):344-8. doi: 10.1111/j.1748-5827.2008.00583.x.
To measure the D-dimer concentrations in both healthy dogs and dogs with and without evidence of thromboembolic disease/disseminated intravascular coagulation using a "Point-of-Care" test.
Sixty-seven clinical cases and 26 healthy dogs were included in this retrospective study. D-dimer was measured using the NycoCard D-dimer test. Clinical conditions were categorised based on clinical findings, laboratory results, imaging, cytology, histopathology, necropsy or a combination of these tests.
There were no dogs for which the NycoCard D-dimer test did not produce a result. The D-dimer range in clinically healthy dogs was 0.1 to 0.5 mg/l (median 0.2 mg/l). In eight of nine cases with thromboembolic disease/disseminated intravascular coagulation and 43 of 58 of the cases without thromboembolic disease/disseminated intravascular coagulation , the D-dimer concentrations were greater than those of healthy dogs.
The NycoCard D-dimer test card required no specialised equipment and could therefore facilitate rapid screening for thromboembolic disease/disseminated intravascular coagulation in first opinion practice. Elevations in D-dimer concentration can be found in a number of clinical conditions apart from thromboembolic disease/disseminated intravascular coagulation and should not therefore be used as the sole basis of diagnosis. D-dimer may be considered a good screening test for thromboembolic disease/disseminated intravascular coagulation as only one case with histopathological evidence of thromboembolic disease/disseminated intravascular coagulation had a D-dimer concentration in the range seen in healthy dogs.
使用“即时检验”方法测量健康犬以及有或无血栓栓塞性疾病/弥散性血管内凝血证据的犬的D-二聚体浓度。
本回顾性研究纳入了67例临床病例和26只健康犬。使用NycoCard D-二聚体检测法测量D-二聚体。根据临床发现、实验室检查结果、影像学、细胞学、组织病理学、尸检或这些检查的综合结果对临床情况进行分类。
没有犬的NycoCard D-二聚体检测未得出结果。临床健康犬的D-二聚体范围为0.1至0.5mg/L（中位数0.2mg/L）。在9例血栓栓塞性疾病/弥散性血管内凝血病例中的8例以及58例无血栓栓塞性疾病/弥散性血管内凝血病例中的43例中，D-二聚体浓度高于健康犬。
NycoCard D-二聚体检测卡不需要专门设备，因此有助于在初诊实践中快速筛查血栓栓塞性疾病/弥散性血管内凝血。除血栓栓塞性疾病/弥散性血管内凝血外，在许多临床情况下均可发现D-二聚体浓度升高，因此不应将其作为诊断的唯一依据。D-二聚体可被视为血栓栓塞性疾病/弥散性血管内凝血的良好筛查试验，因为只有1例有血栓栓塞性疾病/弥散性血管内凝血组织病理学证据的病例其D-二聚体浓度在健康犬所见范围内。
