Feldman B F, Madewell B R, O'Neill S
J Am Vet Med Assoc. 1981 Jul 15;179(2):151-4.
An analysis was made of 41 cases of disseminated intravascular coagulation in dogs, with the objective of evaluating routine and nonroutine laboratory tests used in making the diagnosis. The dogs were grouped on the basis of underlying disease, which included neoplasia (39%), pancreatitis (30%), chronic active hepatitis (15%), heat stroke (12%), and sepsis (4%). Of the diagnostic tests evaluated, those for determination of activated partial thromboplastin time, antithrombin III activity, prothrombin time, and the platelet count were the most valuable. Of the clotting factors, factor V activity was decreased more frequently than the activity of factor VIII:C (factor VIII: procoagulant). The factor VIII:C activity was in conflict with prevailing dogma that reflects depression of this factor in disseminated intravascular coagulation. Factor VIII:C activity was decreased in only 29% of dogs studied. Activation of the fibrinolytic system was manifested by decreased plasminogen activity in 49% of the dogs studied. Sixty-one percent of the dogs had increased amounts of fibrin (ogen) degradation products.
对41例犬弥散性血管内凝血病例进行了分析，目的是评估用于诊断的常规和非常规实验室检查。这些犬根据潜在疾病进行分组，潜在疾病包括肿瘤（39%）、胰腺炎（30%）、慢性活动性肝炎（15%）、中暑（12%）和败血症（4%）。在所评估的诊断检查中，活化部分凝血活酶时间、抗凝血酶III活性、凝血酶原时间和血小板计数的检测最有价值。在凝血因子中，V因子活性比VIII:C因子（VIII因子：促凝血剂）活性更频繁地降低。VIII:C因子活性与普遍认为弥散性血管内凝血时该因子降低的观点相矛盾。在所研究的犬中，仅29%的犬VIII:C因子活性降低。49%的所研究犬中纤溶酶原活性降低表明纤维蛋白溶解系统被激活。61%的犬纤维蛋白（原）降解产物量增加。
