Maeda T, Takenaka H, Yamahira Y, Noguchi T
J Pharm Sci. 1977 Jan;66(1):69-73. doi: 10.1002/jps.2600660117.
A novel procedure to control the stomach emptying rate in rabbits is presented. Rabbits were given a special solid diet for 1 week, and then the gastric contents were washed out with saline. Then the rabbits were muzzled to prevent coprophagy during the night. Fifty grams of special soft diet given to the "stomach-emptying-controlled" rabbit transferred exponentially from the stomach into the small intestine and almost disappeared from the stomach within 5 hr. Griseofulvin, indomethacin, or nalidixic acid was administered in a hard gelatin capsule or tablet, with subsequent feeding of a special soft diet. Good correlations were observed between the plasma level-time curves of these drugs in the stomach-emptying-controlled rabbits and in human subjects.
本文介绍了一种控制家兔胃排空率的新方法。给家兔喂食特殊固体饲料1周，然后用生理盐水冲洗胃内容物。之后给家兔戴上口套以防止其夜间食粪。给“胃排空控制”组家兔喂食50克特殊软饲料，饲料呈指数形式从胃转移至小肠，且在5小时内几乎从胃中消失。将灰黄霉素、吲哚美辛或萘啶酸装入硬明胶胶囊或片剂中给药，随后喂食特殊软饲料。在胃排空控制的家兔和人类受试者中，观察到这些药物的血浆浓度-时间曲线之间具有良好的相关性。
