麻醉性镇痛药对胃排空和药物吸收的抑制作用。
Inhibition of gastric emptying and drug absorption by narcotic analgesics.
作者信息
Nimmo W S, Heading R C, Wilson J, Tothill P, Prescott L F
出版信息
Br J Clin Pharmacol. 1975 Dec;2(6):509-13. doi: 10.1111/j.1365-2125.1975.tb00568.x.
Abstract
The effect of intramuscular pethidine or diamorphine on gastric emptying and the absorption of orally administered paracetamol was assessed in eight normal subjects. 2 Both drugs produced a significant and striking delay in gastric emptying and absorption of paracetamol. 3 It seems inevitable that pethidine and diamorphine will retard the absorption of other orally administered drugs.
摘要
在8名正常受试者中评估了肌肉注射哌替啶或海洛因对胃排空及口服对乙酰氨基酚吸收的影响。两种药物均使对乙酰氨基酚的胃排空和吸收出现显著且明显的延迟。哌替啶和海洛因似乎不可避免地会延缓其他口服药物的吸收。
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