哺乳动物心房的间期-强度关系：一种钙交换模型。I. 理论
The interval-strength relationship in mammalian atrium: a calcium exchange model. I. Theory.
作者信息
Manring A, Hollander P B
出版信息
Biophys J. 1971 Jun;11(6):483-501. doi: 10.1016/S0006-3495(71)86230-6.
A model is developed for predicting the interval-strength relationship in mammalian atrium. The postulates underlying the model relate the intracellular and transmembrane calcium fluxes to changes in contractility. The predictions of the model agree qualitatively with the behavior of atrium for the following patterns of stimulation: (a) constant interval between stimuli, (b) a rest, or period with no stimuli, after the attainment of a steady-state force level, (c) a sudden change in the interval between stimuli, and (d) paired pulse stimulation. The effects of varying several parameters of the model on both the contraction staircases, after a rested-state contraction, and the steady-state interval-strength relationship are examined. Additional considerations are made: (a) estimates are made of the tissue calcium content available for contraction; (b) the physical meaning of the rested-state contraction is discussed; and (c) estimates are made of the proportionality constant between the maximum value of the contractile tension and the amount of calcium released before a contraction.
开发了一个用于预测哺乳动物心房中刺激间隔与强度关系的模型。该模型所依据的假设将细胞内和跨膜钙通量与收缩性变化联系起来。对于以下刺激模式，该模型的预测在定性上与心房的行为一致：(a)刺激之间的间隔恒定；(b)在达到稳态力水平后有一个休息期或无刺激期；(c)刺激之间的间隔突然变化；以及(d)成对脉冲刺激。研究了改变模型的几个参数对静息状态收缩后的收缩阶梯以及稳态刺激间隔与强度关系的影响。还进行了其他考虑：(a)对可用于收缩的组织钙含量进行了估计；(b)讨论了静息状态收缩的物理意义；以及(c)对收缩张力最大值与收缩前释放的钙量之间的比例常数进行了估计。
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