抗体亲和力异质性的免疫病理学意义。
The immunopathological significance of the heterogeneity of antibody affinity.
作者信息
Soothill J F, Steward M W
出版信息
Clin Exp Immunol. 1971 Aug;9(2):193-9.
Abstract
Mice of two inbred strains, prone to nephritis following neonatal lymphocytic choriomeningitis virus infection, produced antibody of lower affinity to two soluble protein antigens, human serum albumin and transferrin, than did two nephritis-resistant strains. Antigen in adjuvant elicited higher affinity antibody than did antigen in saline, in the nephritis-prone mice. The significance of these findings in the pathogenesis and treatment of nephritis, arthritis and other possible soluble complex disease is discussed.
摘要
两种近交系小鼠在新生期感染淋巴细胞性脉络丛脑膜炎病毒后易患肾炎，与两种抗肾炎品系相比，它们产生的针对两种可溶性蛋白质抗原（人血清白蛋白和转铁蛋白）的抗体亲和力较低。在易患肾炎的小鼠中，佐剂中的抗原比盐溶液中的抗原能引发更高亲和力的抗体。本文讨论了这些发现对肾炎、关节炎及其他可能的可溶性复合物疾病的发病机制和治疗的意义。
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