Reinhardt M C, Devey M, Collins M, Gregory B, Steward M W
Clin Exp Immunol. 1981 Jun;44(3):528-37.
Mice genetically selected to produce antibodies of either high or low affinity to protein antigens injected in saline were fed either a normal protein diet or a protein-deficient diet and were given daily injections of HSA for up to 73 days to induce chronic antigen-antibody complex disease. In low-affinity mice fed the normal protein diet, this resulted in impairment of renal function, deposition of immunoglobulin, C3 and HSA in the glomeruli, high levels of circulating antigen-antibody complexes and death from apparent renal failure in 50% of the animals. High-affinity mice on either diet had no impairment of renal function, fewer deposits in the glomeruli, lower levels of circulating complexes and no deaths. Low-affinity mice fed the protein-deficient diet had less impairment of renal function and less glomerular deposition of complexes than did low-affinity mice fed the normal diet. In addition, none of these mice died from renal failure. These results demonstrate that the protein-deficient diet reduced the severity of the experimental chronic antigen-antibody complex disease in low affinity mice but did not increase the susceptibility of high-affinity mice to the disease.
对通过基因选择产生对注射于盐水中的蛋白质抗原有高亲和力或低亲和力抗体的小鼠，分别给予正常蛋白质饮食或蛋白质缺乏饮食，并每天注射人血清白蛋白（HSA）长达73天，以诱发慢性抗原 - 抗体复合物疾病。在喂食正常蛋白质饮食的低亲和力小鼠中，这导致肾功能受损、免疫球蛋白、C3和HSA在肾小球中的沉积、循环抗原 - 抗体复合物水平升高，并且50%的动物因明显的肾衰竭死亡。两种饮食条件下的高亲和力小鼠均无肾功能损害，肾小球中的沉积物较少，循环复合物水平较低，且无死亡情况。与喂食正常饮食的低亲和力小鼠相比，喂食蛋白质缺乏饮食的低亲和力小鼠肾功能损害较轻，复合物在肾小球中的沉积也较少。此外，这些小鼠均未死于肾衰竭。这些结果表明，蛋白质缺乏饮食降低了低亲和力小鼠实验性慢性抗原 - 抗体复合物疾病的严重程度，但并未增加高亲和力小鼠对该疾病的易感性。
