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卡马西平超敏反应中的体内外母细胞转化

Blast transformation in vivo and in vitro in carbamazepin hypersensitivity.

作者信息

Virolainen M

出版信息

Clin Exp Immunol. 1971 Sep;9(3):429-35.

PMID:5571058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1713085/
Abstract

A case is reported in which the number of proliferating blast-like cells substantially increased in peripheral blood during hypersensitivity reaction to carbamazepin (`Tegretol'). The patient's lymphocytes subsequently transformed into blasts in the presence of carbamazepin. In provocation tests, two patients with carbamazepin hypersensitivity showed a significant increase in proliferating blasts in the peripheral blood.

摘要

据报道，有一例在对卡马西平（“得理多”）发生过敏反应期间，外周血中增殖性母细胞样细胞数量大幅增加。随后，该患者的淋巴细胞在卡马西平存在的情况下转化为母细胞。在激发试验中，两名对卡马西平过敏的患者外周血中增殖性母细胞显著增加。

相似文献

1
Blast transformation in vivo and in vitro in carbamazepin hypersensitivity.卡马西平超敏反应中的体内外母细胞转化
Clin Exp Immunol. 1971 Sep;9(3):429-35.
2
Blood lymphoblast proliferation in vivo in cutaneous drug hypersensitivity reactions.皮肤药物超敏反应中体内血液淋巴细胞增殖。
Int Arch Allergy Appl Immunol. 1974;46(2):289-99. doi: 10.1159/000231132.
3
Interferon-gamma production in the peripheral lymphocytes of a patient with carbamazepine hypersensitivity syndrome.卡马西平超敏综合征患者外周淋巴细胞中γ干扰素的产生
Acta Derm Venereol. 2000 Jan-Feb;80(1):73. doi: 10.1080/000155500750012702.
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The lymphocyte transformation test in allergic contact dermatitis.过敏性接触性皮炎中的淋巴细胞转化试验。
South Med J. 1969 Oct;62(10):1204-6. doi: 10.1097/00007611-196910000-00012.
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Reactive lymphocytes in an allergic drug reaction.过敏性药物反应中的反应性淋巴细胞。
Am J Hematol. 2019 Dec;94(12):1423-1424. doi: 10.1002/ajh.25599. Epub 2019 Aug 20.
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[Transformation of human peripheral blood lymphocytes in vitro. 2. Response to antigenic substances and mixed leukocyte cultures].[人外周血淋巴细胞的体外转化。2. 对抗原物质和混合白细胞培养的反应]
Arerugi. 1968 Mar;17(3):210-27.
7
Detection in vitro of cellular hypersensitivity to drugs.药物细胞超敏反应的体外检测。
J Allergy Clin Immunol. 1971 Nov;48(5):276-82. doi: 10.1016/0091-6749(71)90028-5.
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Lymphocyte transformation in vitro measured by tritiated thymidine uptake. I. Lymphocyte culture techniques.通过氚标记胸腺嘧啶核苷摄取法体外测定淋巴细胞转化。I. 淋巴细胞培养技术。
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[Acute hepatic cell damage by simultaneous administration of isonicotinic acid hydrazide and antiepileptic agents in humans, (diphenylhydantoin or carbamazepin)].异烟肼与抗癫痫药（苯妥英或卡马西平）同时给药对人体肝细胞的急性损伤
Med Welt. 1969 Jan 4;1:48-54.
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[Isotopic interpretation of in vitro lymphoblastic transformation test].[体外淋巴细胞转化试验的同位素解释]
Bull Soc Fr Dermatol Syphiligr. 1972;79(2):143-6.

引用本文的文献

1
In Vitro Assays in Severe Cutaneous Adverse Drug Reactions: Are They Still Research Tools or Diagnostic Tests Already?严重皮肤药物不良反应的体外检测：它们仍是研究工具还是已然成为诊断测试？
Int J Mol Sci. 2017 Aug 10;18(8):1737. doi: 10.3390/ijms18081737.
2
In vitro testing for the diagnosis of anticonvulsant hypersensitivity syndrome: a systematic review.抗惊厥药物过敏综合征的体外诊断检测：系统评价。
Mol Diagn Ther. 2009;13(5):313-30. doi: 10.1007/BF03256336.
3
Glandular fever-like syndrome, pulmonary eosinophilia and asthma associated with carbamazepine.与卡马西平相关的腺热样综合征、肺嗜酸性粒细胞增多症和哮喘。
Postgrad Med J. 1982 Feb;58(676):100-1. doi: 10.1136/pgmj.58.676.100.
4
Pulmonary eosinophilia and asthma associated with carbamazepine.与卡马西平相关的肺嗜酸性粒细胞增多症和哮喘。
Br Med J (Clin Res Ed). 1981 Feb 7;282(6262):440. doi: 10.1136/bmj.282.6262.440.
5
Skin test sensitivity and antigen-induced lymphocyte transformation in uraemia.尿毒症患者的皮肤试验敏感性及抗原诱导的淋巴细胞转化
Clin Exp Immunol. 1973 Jul;14(3):365-70.
6
Hypersensitivity to carbamazepine presenting as pseudolymphoma.表现为假性淋巴瘤的卡马西平超敏反应。
J Clin Pathol. 1986 Nov;39(11):1224-8. doi: 10.1136/jcp.39.11.1224.
7
Lymphocyte-stimulation tests and patch tests to carbamazepine hypersensitivity.淋巴细胞刺激试验及卡马西平超敏反应的斑贴试验。
Clin Exp Immunol. 1977 Aug;29(2):272-7.

本文引用的文献

1
DNA AND RNA SYNTHESIS OF CIRCULATING ATYPICAL LYMPHOCYTES IN INFECTIOUS MONONUCLEOSIS.传染性单核细胞增多症中循环非典型淋巴细胞的DNA和RNA合成
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DRUG-INDUCED IN-VITRO STIMULATION OF PERIPHERAL LYMPHOCYTES.药物诱导的外周淋巴细胞体外刺激
Lancet. 1964 Jun 20;1(7347):1368-9. doi: 10.1016/s0140-6736(64)92046-x.
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THE ROLES OF CELLULAR DIVISION AND MATURATION IN THE FORMATION OF PRECIPITATING ANTIBODY.细胞分裂和成熟在沉淀抗体形成中的作用
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Lymphadenopathy induced by anticonvulsant drugs and mimicking clinically pathologically malignant lymphomas.抗惊厥药物所致淋巴结病，临床病理表现酷似恶性淋巴瘤。
Cancer. 1959 Jan-Feb;12(1):164-82. doi: 10.1002/1097-0142(195901/02)12:1<164::aid-cncr2820120122>3.0.co;2-y.
6
Diphenylhydantoin sensitivity; report of fatal case with hepatitis and exfoliative dermatitis.苯妥英钠敏感性；伴有肝炎和剥脱性皮炎的致死病例报告。
N Engl J Med. 1956 Mar 15;254(11):522-3. doi: 10.1056/NEJM195603152541107.
7
Severe para-aminosalicylic acid hypersensitivity simulating mononucleosis or hepatitis.模拟单核细胞增多症或肝炎的严重对氨基水杨酸超敏反应。
J Am Med Assoc. 1953 Jun 13;152(7):606-7. doi: 10.1001/jama.1953.63690070002010a.
8
Lymphoid cellular responses in the blood after immunization in man.人体免疫后血液中的淋巴细胞反应。
J Exp Med. 1969 May 1;129(5):849-69. doi: 10.1084/jem.129.5.849.
9
Localization of afferent lymph cells within the draining node during a primary immune response.初次免疫应答期间传入淋巴细胞在引流淋巴结内的定位。
Nature. 1970 Aug 1;227(5257):510-3. doi: 10.1038/227510a0.
10
The atypical lymphocyte.异型淋巴细胞。
Am J Med. 1967 Jun;42(6):923-36. doi: 10.1016/0002-9343(67)90073-3.