Chopde C T, Brahmankar D M, Shripad V N
J Pharmacol Exp Ther. 1977 Feb;200(2):314-9.
Mice were made physically dependent on ethanol by a 3-day period of alcohol inhalation with small daily injections of pyrazole. During this treatment the concentrations of norepinephrine, dopamine and 5-hydroxytryptamine were increased in brain with concomitant decrease in gamma-aminobutyric acid, RNA and DNA. However, the monoamine concentrations showed complete regression to normal levels at the time of maximal withdrawal seizure when GABA level was still elevated above the control values. Brain RNA and DNA concentrations remained low at this period. During the recovery phase, the pattern of neuronal components was almost the same as was observed at maximal withdrawal seizures. Pyrazole by itself did not produce significant changes in concentrations of the neuronal components of brain.
通过为期3天的酒精吸入并每日小剂量注射吡唑，使小鼠对乙醇产生身体依赖性。在此治疗期间，脑中去甲肾上腺素、多巴胺和5-羟色胺的浓度升高，同时γ-氨基丁酸、RNA和DNA的浓度降低。然而，当γ-氨基丁酸水平仍高于对照值时，在最大戒断性癫痫发作时单胺浓度完全恢复到正常水平。在此期间脑RNA和DNA浓度仍然较低。在恢复阶段，神经元成分的模式与在最大戒断性癫痫发作时观察到的几乎相同。吡唑本身不会使脑中神经元成分的浓度产生显著变化。
