大鼠对同种脑和肝亚细胞组分的免疫反应。
Immune response of rats to subcellular fractions of isologous brain and liver.
作者信息
Shek R P, MacPherson C F
出版信息
Immunology. 1971 Aug;21(2):333-41.
The titres of complement fixing antibodies in the sera of rats injected with the soluble fraction of rat brain emulsified in Freunds' complete adjuvant (FCA) were usually below 10. In contrast, injections of the nuclear, mitochondrial or microsomal fractions of rat brain in FCA were followed by the appearances of heat stable complement fixing and haemagglutinating antibodies within a few days, the highest antibody levels being attained about 6 days after the first injection of a particulate fraction. The microsomal fraction was the most efficient particulate antigen. After 2 weeks of immunization about 60 per cent of the complement fixing activity of the antisera was due to 19S antibody and the remainder to 7S antibody. The response to injections of the nuclear and microsomal fractions of rat liver followed a similar time course but produced levels of complement fixing antibodies that were consistently lower than those engendered by the corresponding brain antigens.
用弗氏完全佐剂（FCA）乳化的大鼠脑可溶性部分注射大鼠后，其血清中补体结合抗体的效价通常低于10。相比之下，在FCA中注射大鼠脑的核、线粒体或微粒体部分后，在几天内就会出现热稳定的补体结合抗体和血凝抗体，在首次注射颗粒部分约6天后达到最高抗体水平。微粒体部分是最有效的颗粒抗原。免疫2周后，抗血清约60%的补体结合活性归因于19S抗体，其余归因于7S抗体。对大鼠肝脏核和微粒体部分注射的反应遵循相似的时间进程，但产生的补体结合抗体水平始终低于相应脑抗原所产生的水平。
Zotero 插件